1030594-69-4Relevant articles and documents
Synthesis and in vitro antibacterial activities of novel oxazolidinones
Srivastava, Brijesh Kumar,Jain, Mukul R.,Solanki, Manish,Soni, Rina,Valani, Darshan,Gupta, Sunil,Mishra, Bhupendra,Takale, Vijay,Kapadnis, Prashant,Patel, Harilal,Pandya, Purvi,Patel, Jayendra Z.,Patel, Pankaj R.
, p. 683 - 693 (2008)
Design and synthesis of novel piperazinylaryloxazolidinones possessing heteroaryl groups are described and their in vitro antibacterial activities have been evaluated by MIC assay. Compounds (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrofuran-2-yl)-acryloyl]-piperazin-1-yl] -phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (6o), (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrothien-2-yl)-acryloyl]-piperazin-1-yl] -phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (6p) and N-oxide of (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrofuran-2-yl)-acryloyl]-piperazin-1-yl] -phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (9) showed superior antibacterial activities than linezolid and also active against the linezolid resistant Staphylococcus aureus strains.