612055-05-7

Basic information

• Product Name: (E)-(S)-N-[3-(3-fluoro-4-[4-(3-(5-nitrofuran-2-yl)-acryloyl-piperazin-1-yl)-3-phenyl]-2-oxo-oxazolidin-5-ylmethyl)]acetamide
• Synonyms: (E)-(S)-N-[3-(3-fluoro-4-[4-(3-(5-nitrofuran-2-yl)-acryloyl-piperazin-1-yl)-3-phenyl]-2-oxo-oxazolidin-5-ylmethyl)]acetamide
• CAS NO: 612055-05-7
• Molecular Weight: 501.471
• Mol File: 612055-05-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-(S)-N-[3-(3-fluoro-4-[4-(3-(5-nitrofuran-2-yl)-acryloyl-piperazin-1-yl)-3-phenyl]-2-oxo-oxazolidin-5-ylmethyl)]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(S)-N-[3-(3-fluoro-4-[4-(3-(5-nitrofuran-2-yl)-acryloyl-piperazin-1-yl)-3-phenyl]-2-oxo-oxazolidin-5-ylmethyl)]acetamide(612055-05-7)
• EPA Substance Registry System: (E)-(S)-N-[3-(3-fluoro-4-[4-(3-(5-nitrofuran-2-yl)-acryloyl-piperazin-1-yl)-3-phenyl]-2-oxo-oxazolidin-5-ylmethyl)]acetamide(612055-05-7)

Safety Data

• Hazardous Substances Data: 612055-05-7(Hazardous Substances Data)

Upstream product

• 154590-66-6 (S)-N-[[3-[3-fluoro-4-(1-piperazinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 15341-58-9 trans-5-nitro-2-furanacrylic acid 

Downstream Products

• 1030594-69-4 C₂₃H₂₄FN₅O₈ 

Relevant articles and documents

Synthesis and in vitro antibacterial activities of novel oxazolidinones

Design and synthesis of novel piperazinylaryloxazolidinones possessing heteroaryl groups are described and their in vitro antibacterial activities have been evaluated by MIC assay. Compounds (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrofuran-2-yl)-acryloyl]-piperazin-1-yl] -phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (6o), (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrothien-2-yl)-acryloyl]-piperazin-1-yl] -phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (6p) and N-oxide of (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrofuran-2-yl)-acryloyl]-piperazin-1-yl] -phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (9) showed superior antibacterial activities than linezolid and also active against the linezolid resistant Staphylococcus aureus strains.

NOVEL ANTIINFECTVE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention describes novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them.