103240-27-3 Usage
Description
N-(3-Oxobutyl) Norfloxacin is a derivative of Norfloxacin (N681000), an antimicrobial agent. It is characterized by its white needle-like chemical appearance and demonstrates enhanced antibacterial activity in vivo when compared to its parent compound, Norfloxacin.
Uses
Used in Pharmaceutical Industry:
N-(3-Oxobutyl) Norfloxacin is used as an antimicrobial agent for its increased effectiveness in combating bacterial infections. Its higher antibacterial activity compared to Norfloxacin makes it a promising candidate for the development of new antibiotics to address the growing concern of antibiotic resistance.
Used in Medical Research:
In the field of medical research, N-(3-Oxobutyl) Norfloxacin can be utilized for studying the mechanisms of bacterial resistance and the development of novel strategies to overcome these resistances. Its potent antibacterial properties can also be explored for potential applications in treating specific bacterial diseases or infections.
Used in Veterinary Medicine:
N-(3-Oxobutyl) Norfloxacin may also find applications in veterinary medicine as an antimicrobial agent for treating bacterial infections in animals. Its enhanced activity could lead to more effective treatments and better outcomes for animals suffering from bacterial diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 103240-27-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,4 and 0 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 103240-27:
(8*1)+(7*0)+(6*3)+(5*2)+(4*4)+(3*0)+(2*2)+(1*7)=63
63 % 10 = 3
So 103240-27-3 is a valid CAS Registry Number.
103240-27-3Relevant articles and documents
Synthesis of Antimicrobial Agents. 3. Syntheses and Antibacterial Activities of 7-(4-Hydroxypiperazin-1-yl)quinolones
Uno, Toshio,Kondo, Hirosato,Inoue, Yoshimasa,Kawahata, Yoshihiro,Sotomura, Mikio,et al.
, p. 2929 - 2932 (1990)
A series of novel pyridone carboxylic acids having a 4-hydroxypiperazinyl group at the 7-position of norfloxacin and ciprofloxacin were prepared.The in vivo antibacterial efficacies of these compounds were superior to those of corresponding piperazinyl derivatives.From the results of the studies on the pharmacokinetic profile and toxicity, the 4-hydroxypiperazinyl derivatives were confirmed to be pharmacologically superior to corresponding piperazinyl derivatives.Thus, a 4-hydroxypiperazinyl group was revealed to be a beneficial substituent for potential use in future quinolone antibacterials.
Studies on Prodrugs. 5. Synthesis and Antimicrobial Activity of N-(Oxoalkyl)norfloxacin Derivatives
Kondo, Hirosato,Sakamoto, Fumio,Kodera, Yasuo,Tsukamoto, Goro
, p. 2020 - 2024 (2007/10/02)
Several N-(oxoalkyl)norfloxacin derivatives (3a-g) were synthesized and evaluated for antibacterial activity in vitro and in vivo.Most of the compounds exhibited in vitro activity comparable to that of norfloxacin for Gram-positive bacteria, whereas their
