1033038-23-1

Basic information

• Product Name: ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate
• Synonyms: ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate
• CAS NO: 1033038-23-1
• Molecular Weight: 314.368
• Mol File: 1033038-23-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate(1033038-23-1)
• EPA Substance Registry System: ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate(1033038-23-1)

Safety Data

• Hazardous Substances Data: 1033038-23-1(Hazardous Substances Data)

Upstream product

• 66129-30-4 6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine-3(2H)-thione 
• 105-39-5 chloroacetic acid ethyl ester 
• 1033038-29-7 (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetic acid(1-methyl-3-oxo-butylidene)-hydrazide 
• 141-52-6 sodium ethanolate 

Downstream Products

• 894061-98-4 (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetamide 
• 1033038-28-6 (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetic acid hydrazide 
• 1033038-24-2 (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetic acid 

Relevant articles and documents

Anti-HAV activity of some newly synthesized triazolo[4,3-b]pyridazines

6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazine-3(2H)-thione 2 was used as precursor for the preparation of some novel 3-S-substituted-6-phenyl-[1,2,4] triazolo[4,3-b]pyridazine derivatives 3-11. Furthermore, the preparation of 1-[2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetyl] -1H-pyrazole derivative 13 and 5-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3- ylsulfanylmethyl)-[1,3,4]oxadiazole derivatives 15 and 17, are described. Some of the prepared products revealed a promising antiviral activity against hepatitis-A virus (HAV, MBB-cell culture adapted strain). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the test compounds. Compound 15 showed the highest effect on HAV compared to the other tested compounds.