66129-30-4

Basic information

• Product Name: 1,2,4-Triazolo[4,3-b]pyridazine-3(2H)-thione, 6-phenyl-
• CAS NO: 66129-30-4
• Molecular Formula: C11H8N4S
• Molecular Weight: 228.277
• Mol File: 66129-30-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazolo[4,3-b]pyridazine-3(2H)-thione, 6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[4,3-b]pyridazine-3(2H)-thione, 6-phenyl-(66129-30-4)
• EPA Substance Registry System: 1,2,4-Triazolo[4,3-b]pyridazine-3(2H)-thione, 6-phenyl-(66129-30-4)

Safety Data

• Hazardous Substances Data: 66129-30-4(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 38956-80-8 3-hydrazino-6-phenylpyridazine 

Downstream Products

• 1033038-27-5 bis-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)disulphide 
• 1033038-26-4 3-(2,2-dimethoxy-ethylsulfanyl)-6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 894061-78-0 3-ethylsulfanyl-6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 1033038-23-1 ethyl-2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)acetate 
• 1033038-24-2 (6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetic acid 

Relevant articles and documents

Anti-HAV activity of some newly synthesized triazolo[4,3-b]pyridazines

6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazine-3(2H)-thione 2 was used as precursor for the preparation of some novel 3-S-substituted-6-phenyl-[1,2,4] triazolo[4,3-b]pyridazine derivatives 3-11. Furthermore, the preparation of 1-[2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetyl] -1H-pyrazole derivative 13 and 5-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3- ylsulfanylmethyl)-[1,3,4]oxadiazole derivatives 15 and 17, are described. Some of the prepared products revealed a promising antiviral activity against hepatitis-A virus (HAV, MBB-cell culture adapted strain). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the test compounds. Compound 15 showed the highest effect on HAV compared to the other tested compounds.