103394-86-1

Basic information

• Product Name: Ethanone, 1-phenyl-2-(phenylmethoxy)-
• Synonyms: 2-(benzyloxy)-1-phenylethan-1-one;α-benzyloxyacetophenone;2-benzyloxy-1-phenyl-ethanone;2-(benzyloxy)-1-phenylethanone;2-benzyloxy-1-phenylethanone;2-Benzyloxyacetophenone
• CAS NO: 103394-86-1
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol File: 103394-86-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 62-64 °C
• Boiling Point: 353.5±25.0 °C(Predicted)
• Density: 1.106±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 1-phenyl-2-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-phenyl-2-(phenylmethoxy)-(103394-86-1)
• EPA Substance Registry System: Ethanone, 1-phenyl-2-(phenylmethoxy)-(103394-86-1)

Safety Data

• Hazardous Substances Data: 103394-86-1(Hazardous Substances Data)

Upstream product

• 13620-31-0 benzyloxyacetonitrile 
• 100-39-0 benzyl bromide 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 100-44-7 benzyl chloride 
• 838-66-4 2-O-benzyl-1-phenylethane-1,2-diol 
• 100-58-3 phenylmagnesium bromide 
• 60656-87-3 benzyloxyacetoaldehyde 
• 98-80-6 phenylboronic acid 
• 98-88-4 benzoyl chloride 
• 3282-32-4 2-diazo-acetophenone 
• 100-51-6 benzyl alcohol 
• 6337-34-4 2,2-dimethyl-5-phenyl-1,3-dioxolan-4-one 
• 611-71-2 MANDELIC ACID 
• 30379-55-6 benzyloxyacetic acid 

Downstream Products

• 80326-02-9 C₁₅H₁₄O₂ 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 1383003-22-2 2-(benzyloxy)methyl-2-phenyl-1,3-dioxolane 
• 1428476-65-6 (S)-1-(benzyloxy)-4-methyl-2-phenylpent-4-en-2-ol 
• 1159373-94-0 1-[2-(benzyl)phenyl]-3,3-bis(methylthio)-2-propene-1-one 
• 78043-55-7 (Z)-1-Phenyl-2-(phenylmethoxy)ethene 
• 69520-20-3 (E)-1-Phenyl-2-(phenylmethoxy)ethene 

Relevant articles and documents

Synthesis of Ketones by C?H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions

A method for the synthesis of ketones from aldehydes and boronic acids via a transition-metal-free C?H functionalization reaction is reported. The method employs nitrosobenzene as a reagent to drive the simultaneous activation of the boronic acid as a boronate and the activation of the C?H bond of the aldehyde as an iminium species that triggers the key C?C bond-forming step via an intramolecular migration from boron to carbon. These findings constitute a practical, scalable, and operationally straightforward method for the synthesis of ketones.

Rhodium-Catalyzed Geminal Oxyfluorination and Oxytrifluoro-Methylation of Diazocarbonyl Compounds

A new reaction for the rhodium-catalyzed geminal-difunctionalization-based fluorination is presented. The substrates are aromatic and aliphatic diazocarbonyl compounds. As the fluorine source a stable and easily accessible benziodoxole reagent was used. A variety of alcohol, phenol, and carboxylic acid reagents were employed to introduce the second functionality. The reaction was extended to trifluoromethylation using a benziodoxolon reagent. The fluorination and trifluoromethylation reactions probably proceed by a rhodium-containing onium ylide type intermediate, which is trapped by either the F or CF3electrophiles.

Silica-supported HClO4 promotes catalytic solvent- and metal-free O-H insertion reactions with diazo compounds

Solvent-free O-H insertion reactions in the presence of diazo carbonyl compounds were carried-out in very mild conditions. Unlike the traditional metal-catalysed version, employing rhodium acetate dimer, this method uses eco-friendly silica-supported HClO4 as the catalyst. Only 0.3 mol% of this Br?nsted acid catalyst, that can also be recycled several times, is necessary to guarantee very good yields (up to 97%) in the O-H insertion reactions. Reaction set-up is simple and permitted the preparation of forty-three α-hydroxy and α-alkoxy esters/ketones in just 1 h and at room temperature.