103700-11-4

Basic information

• Product Name: (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid
• Synonyms: (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid
• CAS NO: 103700-11-4
• Molecular Weight: 319.476
• Mol File: 103700-11-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid(103700-11-4)
• EPA Substance Registry System: (2S,3R)-1-t-butyldimethylsilyl-3-benzyl-4-oxo-2-azetidinecarboxylic acid(103700-11-4)

Safety Data

• Hazardous Substances Data: 103700-11-4(Hazardous Substances Data)

Upstream product

• 82938-50-9 (4S)-N-tert-butyldimethylsilylazetidin-2-one-4-carboxylic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 684262-72-4 4-((2S,3R)-3-Benzyl-4-oxo-azetidin-2-yloxy)-benzoic acid benzhydryl ester 
• 684262-83-7 4-((2R,3R)-3-Benzyl-4-oxo-azetidin-2-yloxy)-benzoic acid benzhydryl ester 
• 256410-14-7 4-[(2R,3R)-3-Benzyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 256410-18-1 4-[(2S,3R)-3-Benzyl-4-oxo-1-((R)-1-phenyl-ethylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 256410-15-8 (2R,3R)-3-Benzyl-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-4-oxo-azetidine-1-carboxylic acid ((R)-1-phenyl-ethyl)-amide 
• 256410-19-2 (2S,3R)-3-Benzyl-2-[4-(4-methyl-piperazine-1-carbonyl)-phenoxy]-4-oxo-azetidine-1-carboxylic acid ((R)-1-phenyl-ethyl)-amide 

Relevant articles and documents

Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h). Copyright