10374-28-4

Basic information

• Product Name: N,N-diethylcyclopropanecarboxaMide
• Synonyms: N,N-diethylcyclopropanecarboxaMide
• CAS NO: 10374-28-4
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.2108
• Mol File: 10374-28-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 224.1±7.0 °C(Predicted)
• Appearance: /
• Density: 0.999±0.06 g/cm3(Predicted)
• PKA: -0.47±0.20(Predicted)
• CAS DataBase Reference: N,N-diethylcyclopropanecarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethylcyclopropanecarboxaMide(10374-28-4)
• EPA Substance Registry System: N,N-diethylcyclopropanecarboxaMide(10374-28-4)

Safety Data

• Hazardous Substances Data: 10374-28-4(Hazardous Substances Data)

Usage

General Description

N,N-diethylcyclopropanecarboxamide is a chemical compound that is typically used in the synthesis of other more complex compounds. It is part of the carboxamide family, which is a group of compounds that contain a functional group consisting of a carbonyl (a carbon-oxygen double bond) and an amine (nitrogen attached to a hydrocarbon), which in this case is a secondary alkyl, specifically diethylamine. This specific type of carboxamide - a cyclic one (the structure forms a ring) where the ring is a cyclopropane - can be used as a base structure in creating other compounds for applications in various industrial and pharmaceutical processes. It is critical to handle it properly due to its chemical characteristics.

Upstream product

• 54947-39-6 cyclopropanecarboxylic acid n-butyl ester 
• 109-89-7 diethylamine 
• 1759-53-1 cyclopropanecarboxylic acid 
• 4023-34-1 cyclopropanecarboxylic acid chloride 

Downstream Products

• 467426-68-2 (±)-(cis)-2-iodocyclopropyl-N,N-diethylcarboxamide 
• 467426-60-4 1-methyl-cyclopropanecarboxylic acid diethylamide 
• 150322-73-9 1-cyclopropyl-2-(2-fluorophenyl)ethanone 
• 2759-52-6 N-phenylcyclopropanecarboxamide 
• 5617-96-9 N-(cyclopropylmethyl)-N-ethylethanamine 

Relevant articles and documents

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids

Cardiolipin (CL) is a phospholipid located in both the eukaryotic mitochondrial inner membrane and the bacterial cell membrane. Some bacterial CLs are known to contain cyclopropane moieties in their acyl chains. Although the CLs are thought to be involved in the innate immune response, there have been few attempts at chemical synthesis of the CLs, and detailed studies of their biological activities are scarce. Thus, we have developed a synthetic route to CLs containing chiral cyclopropane moieties.

Ni-Al Bimetallic Catalyzed Enantioselective Cycloaddition of Cyclopropyl Carboxamide with Alkyne

A Ni-Al bimetallic catalyzed enantioselective cycloaddition reaction of cyclopropyl carboxamides with alkynes has been developed. A series of cyclopentenyl carboxamides were obtained in up to 99% yield and 94% ee. The bifunctional-ligand-enabled bimetallic catalysis proved to be an efficient strategy for the C-C bond cleavage of unreactive cyclopropanes.