103816-19-9

Basic information

• Product Name: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE
• Synonyms: 1-CHLOROCARBONYL-4-PIPERIDINOPERIDINE;forMyl[4-(piperidin-1-yl)piperidin-1-yl]chloranuide;4-Piperidinopiperidine-1-carbonyl chloride;4-Piperidinopiperidine-1-carbonyl chloride
• CAS NO: 103816-19-9
• Molecular Formula: C₁₁H₁₉ClN₂O
• Molecular Weight: 230.73
• EINECS: 1592732-453-0
• Mol File: 103816-19-9.mol
• Article Data: 16

Chemical Properties

• Melting Point: 60-64°C
• Boiling Point: 344.5±31.0 °C(Predicted)
• Appearance: /
• Density: 1.184±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.19±0.20(Predicted)
• CAS DataBase Reference: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE(103816-19-9)
• EPA Substance Registry System: 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE(103816-19-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3261 8 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 103816-19-9(Hazardous Substances Data)

Usage

Description

1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE is an organic compound with the molecular formula C11H20ClN2O. It is a derivative of piperidine, featuring a chlorocarbonyl group attached to the first carbon and a piperidino group at the fourth position. 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE is used as a reactant for the synthesis of various pharmaceutical compounds, including:
1. Macrocyclic ureas as selective Chk1 inhibitors: These inhibitors play a crucial role in the regulation of cell cycle checkpoints, particularly in the context of cancer therapy. By targeting Chk1, these macrocyclic ureas can help in the development of novel anticancer drugs.
2. Etoposide prodrug for dual prodrug-enzyme antitumor therapy: Etoposide is a widely used chemotherapeutic agent. The development of a prodrug version with 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE can enhance the drug's selectivity and efficacy, making it a valuable addition to cancer treatment strategies.
3. Phosphodiesterase 4 (PDE4) inhibitors: PDE4 inhibitors are known for their anti-inflammatory and immunomodulatory properties. They are being investigated for the treatment of various conditions, including chronic obstructive pulmonary disease (COPD), asthma, and inflammatory bowel disease (IBD). 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE can be used as a reactant in the synthesis of these inhibitors, potentially leading to the development of new therapeutic agents.
4. Camptothecin analogs: Camptothecin is a potent anticancer alkaloid that has been used in the development of several chemotherapy drugs. The synthesis of camptothecin analogs using 1-CHLOROCARBONYL-4-PIPERIDINOPIPERIDINE can result in the creation of novel compounds with improved pharmacological properties and reduced side effects.

Upstream product

• 4897-50-1 4-piperidinopiperidin 
• 503-38-8 trichloromethyl chloroformate 
• 143254-82-4 4-piperidinopiperidine-1-carbonyl chloride hydrochloride 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 97682-44-5 irinotecan 
• 760992-18-5 4'-{1-[bis(4-methoxyphenyl)methyl]-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl}-1,1'-biphenyl-4-yl 1,4'-bipiperidine-1'-carboxylate 
• 1181081-94-6 2-{[(5Z)-2-(1,2-diazinan-1-yl)-4-sulfanylidene-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 4-(piperidin-1-yl)piperidine-1-carboxylate 
• 1309982-12-4 23-(1,4'-bipiperidine-1-carbonyloxy)betulinic acid 
• 100286-90-6 irinotecan hydrochloirde 
• 103816-16-6 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin 

Relevant articles and documents

Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities

Cdc37 associates kinase clients to Hsp90 and promotes the development of cancers. Celastrol, a natural friedelane triterpenoid, can disrupt the Hsp90-Cdc37 interaction to provide antitumor effects. In this study, 31 new celastrol derivatives, 2a - 2d , 3a - 3g , and 4a - 4t , were designed and synthesized, and their Hsp90-Cdc37 disruption activities and antiproliferative activities against cancer cells were evaluated. Among these compounds, 4f , with the highest tumor cell selectivity (15.4-fold), potent Hsp90-Cdc37 disruption activity (IC50= 1.9 μM), and antiproliferative activity against MDA-MB-231 cells (IC50= 0.2 μM), was selected as the lead compound. Further studies demonstrated 4f has strong antitumor activities both in vitro and in vivo through disrupting the Hsp90-Cdc37 interaction and inhibiting angiogenesis. In addition, 4f exhibited less toxicity than celastrol and showed a good pharmacokinetics profile in vivo. These findings suggest that 4f may be a promising candidate for development of new cancer therapies.

PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE

Provided herein are relates to derivatives of podophyllotoxin, compositions thereof, and using them for treating various types of cancer in a subject and/or delaying or regressing various types of tumor growths in a subject.

COMPOUNDS FOR INHIBITING CANCER AND VIRUS

The invention relates to compounds for inhibiting a cancer cell or a virus. Particularly, the invention provides compounds for inhibiting, treating and/or preventing cancer and Zika virus.