1041171-19-0

Basic information

• Product Name: [(3,4-dichlorophenyl)ethynyl](trimethyl)silane
• Synonyms: [(3,4-dichlorophenyl)ethynyl](trimethyl)silane
• CAS NO: 1041171-19-0
• Molecular Weight: 243.208
• Mol File: 1041171-19-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(3,4-dichlorophenyl)ethynyl](trimethyl)silane(CAS DataBase Reference)
• NIST Chemistry Reference: [(3,4-dichlorophenyl)ethynyl](trimethyl)silane(1041171-19-0)
• EPA Substance Registry System: [(3,4-dichlorophenyl)ethynyl](trimethyl)silane(1041171-19-0)

Safety Data

• Hazardous Substances Data: 1041171-19-0(Hazardous Substances Data)

Upstream product

• 20555-91-3 3,4-dichloroiodobenzene 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 556112-20-0 3,4-dichlorophenylacetylene 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

The invention relates to novel resolvin compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel resolvin compounds of the invention.

Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors

During our research using a high-throughput screening system for discovery of a new class of human liver glycogen phosphorylase a (hLGPa) inhibitors, a series of 3-(3,4-dichlorophenyl)acrylamide derivatives were synthesized, and their inhibitory activities toward hLGPa were evaluated. Among the derivatives, (2E,2′E)-N,N′-pentane-1,5-diylbis[3-(3,4-dichlorophenyl)acrylamide] (6c) inhibited hLGPa with an IC50 value of 0.023 μM. An X-ray crystallographic study of the enzyme-6c complex showed that the inhibitor is bound at the dimer interface site, where the 3,4-dichlorophenyl moiety interacts hydrophobically with the enzyme.