556112-20-0

Basic information

• Product Name: 3,4-DICHLOROPHENYLACETYLENE
• Synonyms: 3,4-DICHLOROPHENYLACETYLENE;3,4-DICHLORO-1-ETHYNYLBENZENE;1,2-DICHLORO-4-ETHYNYL-BENZENE;1,2-Dichloro-4-ethynylbenzene, 3,4-Dichloro-1-ethynylbenzene;Benzene, 1,2-dichloro-4-ethynyl-
• CAS NO: 556112-20-0
• Molecular Formula: C₈H₄Cl₂
• Molecular Weight: 171.02
• Mol File: 556112-20-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 40-42
• Boiling Point: 225.1 °C at 760 mmHg
• Flash Point: 96 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 0.131mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4-DICHLOROPHENYLACETYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLOROPHENYLACETYLENE(556112-20-0)
• EPA Substance Registry System: 3,4-DICHLOROPHENYLACETYLENE(556112-20-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 556112-20-0(Hazardous Substances Data)

Usage

General Description

3,4-Dichlorophenylacetylene is a chemical compound with the molecular formula C8H4Cl2. It is a clear, colorless liquid that is slightly soluble in water and soluble in organic solvents. 3,4-Dichlorophenylacetylene is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes. It is also used as a building block in the production of other specialty chemicals. 3,4-Dichlorophenylacetylene is known to be a skin and eye irritant and should be handled with caution. It is important to use proper protective equipment and follow safe handling procedures when working with this compound.

InChI:InChI=1/C8H4Cl2/c1-2-6-3-4-7(9)8(10)5-6/h1,3-5H

Upstream product

• 1041171-19-0 [(3,4-dichlorophenyl)ethynyl](trimethyl)silane 
• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 13965-03-2 bis-triphenylphosphine-palladium(II) chloride 
• 1066-54-2 trimethylsilylacetylene 
• 35364-79-5 2-(3,4-dichlorophenyl)ethanol 
• 558-13-4 carbon tetrabromide 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Downstream Products

• 1042988-81-7 3-(3,4-dichlorophenyl)-1-(pyridin-2-yl)prop-2-yn-1-one 
• 19498-74-9 3-(3,4-dichlorophenyl)prop-2-ynoic acid 
• 1201224-75-0 C₁₂H₁₁⁽²⁾HCl₂O 
• 1198353-22-8 5-(3,4-dichlorophenyl)-3-(pyridin-3-yl)isoxazole hydrochloride 
• 1219808-60-2 1-((2R,4S,5S)-4-(4-(3,4-dichlorophenyl)-1H-1,2,3-triazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 1241603-85-9 3-(3,4-dichlorophenyl)-1-phenylprop-2-yn-1-ol 
• 1356486-29-7 1,2-dichloro-4-(3,3,3-trifluoroprop-1-ynyl)benzene 
• 1190964-55-6 silver(I) 3,4-dichlorophenylethynide 
• 1388753-67-0 ((3,4-dichlorophenyl)ethynyl)(trifluoromethyl)sulfane 
• 1256164-20-1 4-(3,4-dichlorophenyl)-1H-1,2,3-triazole 

Relevant articles and documents

DBU-Mediated Synthesis of Aryl Acetylenes or 1-Bromoethynylarenes from Aldehydes

Two well known synthetic organic reactions Ramirez olefination and Corey-fuchs reactions are integrated in one-pot sequential manner for the synthesis of arylacetylenes and 1,3-enynes starting directly from commercially available aldehydes. The bicyclic amidine 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) along with additive NaOH not only exclusively afforded the terminal alkynes directly from the aldehydes, but also enhanced the reaction rate. The dynamic nature of DBU also facilitated the isolation of 1-bromoalkynes intermediate products. Selection of additive from NaOH and H2O served as a switch for the synthesis of terminal alkyne and 1-bromoalkynes, respectively. (Figure presented.).

1,2,3-triazole compounds with antitumor activity and preparation method for 1,2,3-triazole compounds

The present invention relates to three 1,2,3-triazole compounds with aryl structures on the left sides, and the general structural formulae thereof are as shown in the specification. The three compounds have good antitumor activity.

COMPOSITIONS AND METHODS FOR ORGAN PRESERVATION

The invention relates to reducing, preventing or reversing organ damage, reducing and/or preventing stem cell damage and/or death, enhancing organ preservation and/or survival, or enhancing stem cell preservation and/or survival comprising administering a compound of formula A, a compound of any one of formulae 1-49 or 1-111, a lipoxin compound, an oxylipin compound, or a combination of aspirin and an omega-3 fatty acid.