1042149-70-1Relevant articles and documents
Design and synthesis of cyclic acylguanidines as BACE1 inhibitors
Liu, Jia-Kuo,Gu, Wei,Cheng, Xiao-Rui,Cheng, Jun-Ping,Zhou, Wen-Xia,Nie, Ai-Hua
, p. 1327 - 1330 (2015/12/31)
Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD.