10425-64-6Relevant articles and documents
Synthesis of the NK3 receptor antagonist AZD2624 in C-14-, H-3- and C-13-labeled forms
Elmore, Charles S.,Dorff, Peter N.,Powell, Mark E.,Hall, James E.,Simpson, Thomas R.
experimental part, p. 239 - 246 (2012/01/15)
In support of a program to develop an antipsychotic treatment for schizophrenia, three labeled forms of the NK3 receptor antagonist AZD2624 have been prepared. [3H2]AZD2624 was synthesized by tritiodehalogenation for use in receptor
Synthesis of the carbon-14 labeled isotopomers of (R)-N-methyl-3-[2- methylphenoxyl]-benzenepropanamine hydrochloride (atomoxetine hydrochloride, LY139603), and two of its metabolites
Kuo, Fengjiun,Clodfelter, Dean K.,Wheeler, William J.
, p. 615 - 625 (2007/10/03)
Carbon-14 labeled Straterra (Atomoxetine HC1, LY139603, (-)-N-methyl-3-(2-methylphenoxy)-benzenepropanamine hydrochloride), a potent inhibitor of the presynaptic norepinephrine transporter, and two of its major metabolites were synthesized. The key compon
Synthesis of [carbonyl-14C]-4-benzoylbenzoic acid, a photolabelling reagent
Gomis, Jean-Marie,Santolini,Andre,Noel
, p. 1175 - 1182 (2007/10/03)
[carbonyl-14C]-4-Benzoylbenzoic acid, a photolabelling reagent, was synthesised with high specific activity in 57% radioactive yield from [carboxyl-14C]-benzoic acid. Radioactive synthesis allowed elucidation of the mechanism of a previous unlabelled synthesis using benzoic acid, methyl ester. An improvement in the experimental conditions led to a new synthesis of radioactive benzoylbenzoic derivatives with good yield.
