104384-69-2

Basic information

• Product Name: 1-Propanone, 2-bromo-1-[2-(trifluoromethyl)phenyl]-
• CAS NO: 104384-69-2
• Molecular Formula: C10H8BrF3O
• Molecular Weight: 281.072
• Mol File: 104384-69-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-bromo-1-[2-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-bromo-1-[2-(trifluoromethyl)phenyl]-(104384-69-2)
• EPA Substance Registry System: 1-Propanone, 2-bromo-1-[2-(trifluoromethyl)phenyl]-(104384-69-2)

Safety Data

• Hazardous Substances Data: 104384-69-2(Hazardous Substances Data)

Usage

General Description

1-Propanone, 2-bromo-1-[2-(trifluoromethyl)phenyl]- is a chemical compound with the molecular formula C10H8BrF3O. It is a brominated derivative of 1-Propanone, also known as acetone. 1-Propanone, 2-bromo-1-[2-(trifluoromethyl)phenyl]- is a colorless, highly volatile liquid with a sweet, fruity odor. It is used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used as a solvent and in the manufacturing of various products including plastics, textiles, and pharmaceuticals. The presence of the bromine and trifluoromethyl groups in the molecule make it a versatile compound for use in the synthesis of other complex organic compounds.

Upstream product

• 197508-95-5 1-(2-trifluoromethylphenyl)-1-propanol 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 16185-96-9 1-(2-(trifluoromethyl)phenyl)propan-1-one 

Downstream Products

• 1632006-28-0 ((S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-4[⁽¹⁴⁾C]-pyrrole-3-carboxamide) 
• 1072195-82-4 (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide 
• 1232395-02-6 [3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-[3-methyl-2-(2-trifluoromethylphenyl)imidazo[1,2-a]pyridin-8-yl]amine 
• 1381869-22-2 8-bromo-3-methyl-2-(2-trifluoromethylphenyl)imidazo[1,2-a]pyridine 

Relevant articles and documents

Diminished reactivity of ortho-substituted phenacyl bromides toward nucleophilic displacement

A systematic increase of substitution rates by tert-butylamine on α-bromopropiophenones is observed with meta or para substituents with increasing electron-withdrawing ability (k x 103 L M-1 min-1 = 12.7 (p-CH3), 15.7 (o-F), 20.5 (H), 20.0 (p-Cl), 23.6 (m-Cl), 27.3 (p-CF3)). Within an ortho-substituted series, the reactivities decrease (k x 103 L M-1 min-1 = 7.64 (o-OCH3), 5.31 (o-CH3), 2.85 (o-Cl), 2.40 (o-CF3)). Ortho-substitution results occur from rotational barrier effects and an Aδσ + Bδσ + repulsion. The major bonding contribution between reaction and α-substituent centers (A-B) is only the σ bond. When π bonding is allowed between A and B (meta/para-substitution), delocalization and stabilization of the reacting center occurs.

Method for producing pyrrole derivative, and intermediate thereof

The present invention provides a method for producing an atropisomer of a pyrrole derivative having an exceptional mineralocorticoid receptor antagonizing effect, and an intermediate thereof. A method for producing an atropisomer of a pyrrole derivative using a compound represented by (B) [in the formula, R1 indicates a C1-C4 alkyl group, and R2 indicates a 2-hydroxyethyl group or carboxymethyl group] as a production intermediate.

DIPYRROMETHENE CRYSTAL AND METHOD FOR MANUFACTURING SAME

The present invention refers to mineral excellent pyrrole derivatives having an antagonistic effect on receptor [...] atropisomers of intermediates for preparations of the same, provides concentration and recording medium storing record manufacturing method. 5beta eggs skeleton and optically active amines, which over a long period of time, characterized by, the general formula (I) [In formula, R 1 the methyl or trifluoromethyl indicates the, R 2 hydrogen atom, alkyl having C1-C3 alkoxy groups indicates the, n the exhibits is an integer selected from 1 ～ 3] atropisomers of including process and method for splitting, and manufacturing method isomers atropisomers of pyrrole derivatives (S)-1-(2-hydroxyethyl)-4-methyl-N-[ 4-(methylsulfonyl) phenyl]-5-[ 2-(trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide determination of. (by machine translation)