104773-44-6

Basic information

• Product Name: (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester
• Synonyms: (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester
• CAS NO: 104773-44-6
• Molecular Weight: 309.319
• Mol File: 104773-44-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester(104773-44-6)
• EPA Substance Registry System: (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester(104773-44-6)

Safety Data

• Hazardous Substances Data: 104773-44-6(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 148017-60-1 (1R,5S,6S)-2-[(3S,5S)-5-(1,1-dioxo-2-p-methoxybenzyloxycarbonyl-3,4,5,6-tetrahydro-1,2,6-thiadiazin-6-yl)methyl-1-p-methoxybenzyloxycarbonylpyrrolidin-3-yl]thio-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylic acid p-methoxybenzyl ester 
• 148017-59-8 (1R,5S,6S)-2-[(3S,5S)-5-(1,1-dioxo-2-p-methoxybenzyloxycarbonyl-1,2,5-thiadiazolidin-5-yl)methyl-1-p-methoxybenzyloxycarbonylpyrrolidin-3-yl]thio-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carba-2-penem-3-carboxylic acid p-methoxybenzylester 
• 148017-54-3 C₄₁H₄₈N₄O₁₃S₂ 
• 175846-25-0 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-{(3S,5S)-1-(4-methoxy-benzyloxycarbonyl)-5-[(4-methoxy-benzyloxycarbonylamino)-methyl]-pyrrolidin-3-ylsulfanyl}-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 175846-24-9 6-[(2S,4S)-1-(4-Methoxy-benzyloxycarbonyl)-4-tritylsulfanyl-pyrrolidin-2-ylmethyl]-1,1-dioxo-1λ⁶-[1,2,6]thiadiazinane-2-carboxylic acid 4-methoxy-benzyl ester 
• 175846-23-8 5-[(2S,4S)-1-(4-Methoxy-benzyloxycarbonyl)-4-tritylsulfanyl-pyrrolidin-2-ylmethyl]-1,1-dioxo-1λ⁶-[1,2,5]thiadiazolidine-2-carboxylic acid 4-methoxy-benzyl ester 
• 175846-37-4 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-{(3S,5S)-1-(4-methoxy-benzyloxycarbonyl)-5-[(morpholine-4-sulfonylamino)-methyl]-pyrrolidin-3-ylsulfanyl}-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 148017-58-7 C₃₄H₄₄N₄O₁₁S₂ 
• 175846-35-2 (4R,5S,6S)-3-[(3S,5S)-5-(Carbamoylmethanesulfonylamino-methyl)-1-(4-methoxy-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 175846-36-3 (4R,5S,6S)-3-[(3S,5S)-5-[(2-Hydroxy-ethanesulfonylamino)-methyl]-1-(4-methoxy-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 148016-96-0 (2S,4S)-1-p-methoxybenzyloxycarbonyl-4tritylthio-2-(p-methoxybenzyloxycarbonylaminosulfonylaminomethyl)pyrrolidine 
• 175846-30-7 C₃₄H₄₂N₄O₁₀S 
• 175846-31-8 (4R,5S,6S)-3-[(3S,5S)-5-(2,4-Dioxo-imidazolidin-1-ylmethyl)-1-(4-methoxy-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 175846-28-3 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-((3S,5S)-1-(4-methoxy-benzyloxycarbonyl)-5-{[(pyridine-3-carbonyl)-amino]-methyl}-pyrrolidin-3-ylsulfanyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 

Relevant articles and documents

A novel 1β-methylcarbapenem antibiotic, S-4661 synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1β-methylcarbapenems

The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acids are described. These compounds exhibit potent antibacterial activity against a wide range of both Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa. Of these new carbapenems, (1R,5S,6S)-2-[(3S,5S)-5-sulfamoylaminomethyl pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid (S-4661) showed the most potent and well balanced activity and was selected as a candidate for further evaluation.