148017-54-3

Basic information

• Product Name: C₄₁H₄₈N₄O₁₃S₂
• Synonyms: C₄₁H₄₈N₄O₁₃S₂
• CAS NO: 148017-54-3
• Molecular Weight: 868.983
• Mol File: 148017-54-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₁H₄₈N₄O₁₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₁H₄₈N₄O₁₃S₂(148017-54-3)
• EPA Substance Registry System: C₄₁H₄₈N₄O₁₃S₂(148017-54-3)

Safety Data

• Hazardous Substances Data: 148017-54-3(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 148016-88-0 (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-carboxylic acid methyl ester 
• 148016-92-6 (2S,4S)-2-aminomethyl-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine 
• 148016-89-1 (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol 
• 148016-87-9 (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylic acid methyl ester 
• 104773-44-6 (2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 148016-96-0 (2S,4S)-1-p-methoxybenzyloxycarbonyl-4tritylthio-2-(p-methoxybenzyloxycarbonylaminosulfonylaminomethyl)pyrrolidine 
• 148016-93-7 (2S,4S)-1-p-methoxybenzyloxycarbonyl-2-phthalimidomethyl-4-tritylthiopyrrolidine 
• 148016-90-4 (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate 

Downstream Products

• 148016-81-3 doripenem 

Relevant articles and documents

A novel 1β-methylcarbapenem antibiotic, S-4661 synthesis and structure-activity relationships of 2-(5-substituted pyrrolidin-3-ylthio)-1β-methylcarbapenems

The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acids are described. These compounds exhibit potent antibacterial activity against a wide range of both Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa. Of these new carbapenems, (1R,5S,6S)-2-[(3S,5S)-5-sulfamoylaminomethyl pyrrolidin-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid (S-4661) showed the most potent and well balanced activity and was selected as a candidate for further evaluation.