1050440-92-0 Usage
Description
Potassium 1-Boc-1H-indole-5-trifluoroborate is an organic compound that serves as a key intermediate in various chemical reactions and synthesis processes. It is characterized by its unique structure, which includes a potassium ion, a Boc-protected indole, and a trifluoroborate group. Potassium 1-Boc-1H-indole-5-trifluoroborate is particularly useful in the field of organic chemistry due to its reactivity and versatility in different reaction types.
Uses
Used in Chemical Synthesis:
Potassium 1-Boc-1H-indole-5-trifluoroborate is used as a substrate for various chemical reactions, including cross-coupling, fluorination, and nitrosation reactions. Its application in these reactions is due to its ability to facilitate the formation of new chemical bonds and the introduction of functional groups, which are essential for the synthesis of complex organic molecules.
Used in Cross-Coupling Reactions:
In the application industry of chemical synthesis, Potassium 1-Boc-1H-indole-5-trifluoroborate is used as a substrate for cross-coupling reactions with 2(chloromethyl)-2,1-borazaronaphthalenes. This application is significant because it allows for the formation of new carbon-carbon bonds, which are crucial for the construction of complex molecular structures.
Used in Fluorination Reactions:
Potassium 1-Boc-1H-indole-5-trifluoroborate is also used as a substrate in fluorination reactions of potassium salts of aryl and heteroaryl trifluoroborates. The application reason is to introduce fluorine atoms into the molecular structure, which can significantly impact the reactivity, stability, and biological activity of the resulting compounds.
Used in Nitrosation Reactions:
Furthermore, Potassium 1-Boc-1H-indole-5-trifluoroborate is utilized in nitrosation reactions using nitrosonium tetrafluoroborate. This application is important for the introduction of nitroso functional groups into organic molecules, which can be used in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1050440-92-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,5,0,4,4 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1050440-92:
(9*1)+(8*0)+(7*5)+(6*0)+(5*4)+(4*4)+(3*0)+(2*9)+(1*2)=100
100 % 10 = 0
So 1050440-92-0 is a valid CAS Registry Number.
1050440-92-0Relevant articles and documents
Scope of the palladium-catalyzed aryl borylation utilizing bis-boronic acid
Molander, Gary A.,Trice, Sarah L. J.,Kennedy, Steven M.,Dreher, Spencer D.,Tudge, Matthew T.
supporting information; experimental part, p. 11667 - 11673 (2012/09/05)
The Suzuki-Miyaura reaction has become one of the more useful tools for synthetic organic chemists. Until recently, there did not exist a direct way to make the most important component in the coupling reaction, namely the boronic acid. Current methods to make boronic acids often employ harsh or wasteful reagents to prepare boronic acid derivatives and require additional steps to afford the desired boronic acid. The scope of the previously reported palladium-catalyzed, direct boronic acid synthesis is unveiled, which includes a wide array of synthetically useful aryl electrophiles. It makes use of the newly available second generation Buchwald XPhos preformed palladium catalyst and bis-boronic acid. For ease of isolation and to preserve the often sensitive C-B bond, all boronic acids were readily converted to their more stable trifluoroborate counterparts.
A general and highly selective chelate-controlled intermolecular oxidative heck reaction
Delcamp, Jared H.,Brucks, Alexandria P.,White, M. Christina
supporting information; experimental part, p. 11270 - 11271 (2009/02/05)
A novel chelate-controlled intermolecular oxidative Heck reaction is reported that proceeds with a wide range of nonresonance stabilized α-olefin substrates and organoboron reagents to afford internal olefin products in good yields and outstanding regio- and E:Z stereoselectivities. Pd-H isomerization, common in many Heck reactions, is not observed under these mild, oxidative conditions. This is evidenced by outstanding E:Z selectivities (>20:1 in all cases examined), no erosion in optical purity for proximal stereogenic centers, and a tolerance for unprotected alcohols. Remarkably, a single metal/ligand combination, Pd/bis-sulfoxide complex 1, catalyzes this reaction over a broad range of coupling partners. Given the high selectivities and broad scope, we anticipate this intermolecular Heck reaction will find heightened use in complex molecule synthesis. Copyright
