129822-47-5

Basic information

• Product Name: 1-(tert-Butoxycarbonyl)-5-fluoroindole
• Synonyms: 1-(tert-Butoxycarbonyl)-5-fluoroindole;N-Boc-5-fluoroindole;5-Fluoro-N-(BOC)indole;TERT-BUTYL 5-FLUORO-1H-INDOLE-1-CARBOXYLATE
• CAS NO: 129822-47-5
• Molecular Formula: C₁₃H₁₄FNO₂
• Molecular Weight: 235.257
• Mol File: 129822-47-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 322.3°C at 760 mmHg
• Flash Point: 148.7°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.000282mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 1-(tert-Butoxycarbonyl)-5-fluoroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-Butoxycarbonyl)-5-fluoroindole(129822-47-5)
• EPA Substance Registry System: 1-(tert-Butoxycarbonyl)-5-fluoroindole(129822-47-5)

Safety Data

• Hazardous Substances Data: 129822-47-5(Hazardous Substances Data)

Usage

Description

1-(tert-Butoxycarbonyl)-5-fluoroindole is a chemical compound with the formula C15H18FINO2. It is an indole derivative featuring a fluoro substituent at the 5-position and a tert-butoxycarbonyl group at the 1-position. 1-(tert-Butoxycarbonyl)-5-fluoroindole is recognized for its potential biological activities, including anti-inflammatory and antimicrobial properties. It has been explored for applications in medicine, particularly for the treatment of cancer and neurological disorders, as well as in the synthesis of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Synthesis:
1-(tert-Butoxycarbonyl)-5-fluoroindole serves as a crucial building block in the organic synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 1-(tert-Butoxycarbonyl)-5-fluoroindole is utilized in the synthesis of compounds designed to protect crops from pests and diseases, leveraging its chemical properties to create effective solutions.
Used in Cancer Treatment Research:
1-(tert-Butoxycarbonyl)-5-fluoroindole is investigated for its potential role in cancer treatment. Its biological activities suggest that it may contribute to the development of therapies for various types of cancer.
Used in Neurological Disorder Treatment Research:
1-(tert-Butoxycarbonyl)-5-fluoroindole is also being studied for its possible applications in the treatment of neurological disorders. The anti-inflammatory properties of 1-(tert-Butoxycarbonyl)-5-fluoroindole make it a candidate for further research into neuroprotective and therapeutic agents.
Used in Anti-Inflammatory and Antimicrobial Agents:
Due to its inherent anti-inflammatory and antimicrobial properties, 1-(tert-Butoxycarbonyl)-5-fluoroindole is considered for the development of new agents to combat inflammation and infections in various medical and healthcare applications.

InChI:InChI=1/C13H14FNO2/c1-13(2,3)17-12(16)15-7-6-9-8-10(14)4-5-11(9)15/h4-8H,1-3H3

Upstream product

• 138343-98-3 5-Fluoro-2-hydroxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 399-52-0 5-fluoro-1H-indole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 452-71-1 4-fluor-2-methylaniline 
• 129822-40-8 tert-butyl (4-fluoro-2-methylphenyl)carbamate 
• 777061-36-6 1,1-dimethylethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate 
• 182344-70-3 5-bromo-indole-1-carboxylic acid tert-butyl ester 
• 1063716-87-9 Pd(C₅H₅N)(C₁₃H₈N₂SO₂C₆H₄NO₂)(C₆H₃C₂H₂NC(O)OC(CH₃)3) 
• 1167418-11-2 N-Boc-indole-5-boronic acid neopentylglycol ester 
• 317830-84-5 (1-(tert-butoxycarbonyl)-1H-indol-5-yl)boronic acid 
• 4248-19-5 tert-butyl carbazate 
• 1050440-92-0 1-(tert-butyloxycarbonyl)-1H-indol-5-ylpotassium trifluoroborates 

Downstream Products

• 352359-23-0 [1-(tert-butoxycarbonyl)-5-fluoro-1H-indol-2-yl]boronic acid 
• 1205744-84-8 N-Boc-5-fluoro-2-(4-trifluoromethylphenyl)indole 
• 1621886-94-9 2-(4-fluorophenyl)-5-(10-fluoropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1621886-95-0 5-(10-fluoro-6-oxo-5, 6-dihydropyrido[3',2':4,5]pyrimido[1,6-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1000183-52-7 4-(5-fluoro-1H-indol-3-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine 
• 1000183-49-2 4-(5-fluoro-1H-indol-3-yl)-N-(4-piperazin-1-ylphenyl)pyrimidin-2-amine 
• 1000182-81-9 N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono 
• 1000183-41-4 2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate 
• 1000183-39-0 N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide 
• 1000183-35-6 4-(5-fluoro-1H-indol-3-yl)-N-(4-{4-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]piperazin-1-yl}phenyl)pyrimidin-2-amine 
• 1000183-48-1 tert-butyl 3-[2-({4-[4-(tert-butoxycarbonyl)piperazin-1-yl]phenyl} amino)pyrimidin-4-yl]-5-fluoro-1H-indole-1-carboxylate 
• 1000182-49-9 4-(5-fluoro-1H-indol-3-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine hydrochloride 
• 1000182-82-0 N-{4-[4-(cyclopropylcarbonyl)piperazin-1-yl]phenyl}-4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-amine mono trifluoroacetic acid 
• 1000183-42-5 2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid 

Relevant articles and documents

Carbon–Fluorine Reductive Elimination from Nickel(III) Complexes

We report a C?F reductive elimination from a characterized first-row aryl metal fluoride complex. Reductive elimination from the presented nickel(III) complexes is faster than C?F bond formation from any other characterized aryl metal fluoride complex.

Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- And C3-Borylated Indolines

Indole dearomatization is an important strategy to access indolines: a motif present in a variety of natural products and biologically active molecules. Herein, a method for transition-metal catalyzed regioselective dearomative arylboration of indoles to

INDOLO-SUBSTITUTED-PIPERIDINE COMPOUNDS AS ESTROGEN RECEPTOR DEGRADING AGENT

Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof as an estrogen receptor down-regulator in preparing drugs for treating estrogen receptor-positive breast cancer.