10523-68-9 Usage
Description
2-Adamantanamine hydrochloride is a white crystalline powder with significant applications in various industries, including pharmaceuticals, agrochemicals, and dyestuff. It is an important raw material and intermediate used in organic synthesis.
Uses
Used in Pharmaceutical Industry:
2-Adamantanamine hydrochloride is used as a key intermediate for the preparation of 2-adamantylamide of 2'-(carboxymethoxime)-olivomycin I, which has potential applications in the development of new drugs.
Used in Analytical Chemistry:
2-Adamantanamine hydrochloride is used as a subject for the HPLC assay after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole, allowing for the study and analysis of its chemical properties.
Used in Organic Synthesis:
As an important raw material, 2-Adamantanamine hydrochloride is used as a building block in the synthesis of various organic compounds, contributing to the development of new molecules with potential applications in different fields.
Used in Agrochemicals:
2-Adamantanamine hydrochloride is used as a crucial intermediate in the development of agrochemicals, such as pesticides and fertilizers, to improve agricultural productivity and crop protection.
Used in Dye Industry:
The compound is also utilized as an intermediate in the synthesis of dyes, contributing to the creation of new and vibrant colors for various applications.
Used in CD73 Inhibitors:
2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors, which are potential treatments for CD73-associated diseases, including cancer and immune-related disorders. These inhibitors may help modulate immune responses and exhibit therapeutic effects against certain health conditions.
Purification Methods
The free amine in Et2O, liberated by the action of alkali in H2O, is dried over KOH, filtered, evaporated and sublimed at 110o/12torr, m 230-236o. The base is dissolved in EtOH, sufficient ethanolic HCl is added dropwise and crystallised by the addition of Et2O. Dry it in vacuo. [Stetter et al. Justus Liebigs Ann Chem 658 151 1962].
Check Digit Verification of cas no
The CAS Registry Mumber 10523-68-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,2 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10523-68:
(7*1)+(6*0)+(5*5)+(4*2)+(3*3)+(2*6)+(1*8)=69
69 % 10 = 9
So 10523-68-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H17N/c11-10-8-2-6-1-7(4-8)5-9(10)3-6/h6-10H,1-5,11H2/p+1
10523-68-9Relevant articles and documents
Cerium-Catalyzed C-H Functionalizations of Alkanes Utilizing Alcohols as Hydrogen Atom Transfer Agents
An, Qing,Chen, Yuegang,Liu, Weimin,Pan, Hui,Wang, Xin,Wang, Ziyu,Zhang, Kaining,Zuo, Zhiwei
supporting information, p. 6216 - 6226 (2020/04/27)
Modern photoredox catalysis has traditionally relied upon metal-to-ligand charge-transfer (MLCT) excitation of metal polypyridyl complexes for the utilization of light energy for the activation of organic substrates. Here, we demonstrate the catalytic application of ligand-to-metal charge-transfer (LMCT) excitation of cerium alkoxide complexes for the facile activation of alkanes utilizing abundant and inexpensive cerium trichloride as the catalyst. As demonstrated by cerium-catalyzed C-H amination and the alkylation of hydrocarbons, this reaction manifold has enabled the facile use of abundant alcohols as practical and selective hydrogen atom transfer (HAT) agents via the direct access of energetically challenging alkoxy radicals. Furthermore, the LMCT excitation event has been investigated through a series of spectroscopic experiments, revealing a rapid bond homolysis process and an effective production of alkoxy radicals, collectively ruling out the LMCT/homolysis event as the rate-determining step of this C-H functionalization.