562105-40-2

Basic information

• Product Name: Ristomycin A aglycone, 22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-41-((tricyclo(3.3.1.13,7)dec-2-ylamino)methyl)-
• CAS NO: 562105-40-2
• Molecular Weight: 1362.2
• Mol File: 562105-40-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ristomycin A aglycone, 22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-41-((tricyclo(3.3.1.13,7)dec-2-ylamino)methyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ristomycin A aglycone, 22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-41-((tricyclo(3.3.1.13,7)dec-2-ylamino)methyl)-(562105-40-2)
• EPA Substance Registry System: Ristomycin A aglycone, 22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-41-((tricyclo(3.3.1.13,7)dec-2-ylamino)methyl)-(562105-40-2)

Safety Data

• Hazardous Substances Data: 562105-40-2(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 10523-68-9 adamantan-2-amine hydrochloride 
• 89139-42-4 tiecoplanin aglycon 

Relevant articles and documents

Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics

A variety of semisynthetic derivatives of natural antibacterial glycopeptide antibiotics such as vancomycin, eremomycin, ristocetin A, teicoplanin A2-2, DA-40926, their aglycons, and also the products of their partial degradation with a destroyed or modified peptide core show marked anti-retroviral activity in cell culture. In particular, aglycon antibiotic derivatives containing various substituents of a preferably hydrophobic nature displayed activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and Moloney murine sarcoma virus at a 50% inhibitory concentration in the lower micromolar (1-5 μM) concentration range while not being cytostatic against human lymphocytic cells at 250 μM or higher. The mode of anti-HIV action of the antibiotic aglycon derivatives could be ascribed to inhibition of the viral entry process.