10533-83-2

Basic information

• Product Name: Benzamide, N-methyl-N-[(4-methylphenyl)sulfonyl]-
• CAS NO: 10533-83-2
• Molecular Formula: C15H15NO3S
• Molecular Weight: 289.355
• Mol File: 10533-83-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzamide, N-methyl-N-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-methyl-N-[(4-methylphenyl)sulfonyl]-(10533-83-2)
• EPA Substance Registry System: Benzamide, N-methyl-N-[(4-methylphenyl)sulfonyl]-(10533-83-2)

Safety Data

• Hazardous Substances Data: 10533-83-2(Hazardous Substances Data)

Upstream product

• 6971-74-0 N-benzoyl-p-toluenesulfonamide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 98-59-9 p-toluenesulfonyl chloride 
• 65-85-0 benzoic acid 
• 74-88-4 methyl iodide 
• 4083-64-1 Tosyl isocyanate 
• 5079-90-3 (E)-2-styrylbenzoic acid 
• 88070-48-8 N-methylbenzamide 
• 98-88-4 benzoyl chloride 
• 640-61-9 N-methyl-p-toluenesulfonylamide 

Downstream Products

• 1485-70-7 N-benzylbenzamide 
• 120-51-4 benzoic acid benzyl ester 
• 134-84-9 4-Methylbenzophenone 
• 119-61-9 benzophenone 
• 131-58-8 2-Methylbenzophenone 
• 643-65-2 3-methyl benzophenone 
• 22679-42-1 2-ethylbenzophenone 
• 2553-04-0 ortho-methoxybenzophenone 
• 6136-67-0 3-methoxybenzophenone 
• 611-94-9 4-Methoxybenzophenone 
• 345-83-5 4-fluorobenzophenone 
• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 642-29-5 1-benzoylnaphthalene 
• 613-37-6 4-methoxylbiphenyl 

Relevant articles and documents

N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls

The photochemical fragmentation of N-aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous-flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by-products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.

Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides

A simple protocol, which is catalyst-free, metal-free, and chemoselective, for transamidation of activated secondary amides in ethanol as solvent under mild conditions is reported. A wide range of amines, amino acids, amino alcohols, and the substituents, which are problematic in catalyzed transamidation, are tolerated in this methodology. The transamidation reaction was successfully extended to water as the medium as well. The present methodology appears to be better than the other catalyzed transamidations reported recently.

Highly efficient synthesis of aryl ketones by PEPPSI-palladium catalyzed acylative Suzuki coupling of amides with diarylborinic acids

An improved acylative cross-coupling of various N-methyl-N-tosyl amides with diarylborinic acids for synthesis of aryl ketones is developed. In most cases, aryl ketones could be obtained in excellent yields by using 1 mol% 2,6-diisopropylphenylimidazolylidene and 3-chloropyridine co-supported palladium chloride as catalyst in the presence of 3 equiv. K2CO3 as base in refluxing THF. The readily prepared and cost-effective substrates, N-methyl-N-tosylamides and diarylborinic acids, and the commercially available catalyst system promise a practical and efficient access to aryl ketones.