10538-48-4 Usage
Description
3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID, a phenylalkylcarboxylic acid, is a chemical compound characterized by its unique structure that features a phenyl ring with two methoxy groups at the 2nd and 3rd positions, attached to a propanoic acid chain. This structure endows it with specific properties that make it valuable in various applications, particularly in the field of pharmaceuticals and biochemistry.
Uses
Used in Pharmaceutical Industry:
3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID is used as a key intermediate compound for the synthesis of 5-HT2c receptor agonists, which are biologically active compounds. These agonists play a crucial role in modulating various physiological processes and have potential therapeutic applications in treating a range of disorders, including mood and anxiety disorders, as well as certain neurological conditions.
The synthesis of 5-HT2c receptor agonists from 3-(2,3-DIMETHOXYPHENYL)PROPANOIC ACID involves a series of chemical reactions that exploit the compound's reactivity and functional groups. The end products, once synthesized, can be subjected to further testing and optimization to enhance their efficacy, selectivity, and safety profile for use in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 10538-48-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,3 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10538-48:
(7*1)+(6*0)+(5*5)+(4*3)+(3*8)+(2*4)+(1*8)=84
84 % 10 = 4
So 10538-48-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H14O4/c1-14-9-5-3-4-8(11(9)15-2)6-7-10(12)13/h3-5H,6-7H2,1-2H3,(H,12,13)/p-1
10538-48-4Relevant articles and documents
BENZOSUBERENE ANALOGUES AND RELATED COMPOUNDS WITH ACTIVITY AS ANTICANCER AGENTS
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Paragraph 0071, (2020/03/01)
A series of benzosuberene analogues demonstrate effective inhibition of tubulin polymerization, cytotoxicity against human cancer cell lines, and vascular disruption in tumors.
BENZOCYCLOOCTENE-BASED AND INDENE-BASED ANTICANCER AGENTS
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Paragraph 0084, (2018/02/27)
Benzocyclooctene (fused 6,8 ring system) analogues and corresponding indene (fused 6,5 ring system) analogues function as inhibitors of tubulin polymerization. The compounds are useful as anticancer agents in a new therapeutic approach for cancer treatment utilizing small-molecule inhibitors of tubulin polymerization that also act as vascular disrupting agents (VDAs).
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4)
Day, Jonathan P.,Lindsay, Barbara,Riddell, Tracy,Jiang, Zhong,Allcock, Robert W.,Abraham, Achamma,Sookup, Sebastian,Christian, Frank,Bogum, Jana,Martin, Elisabeth K.,Rae, Robert L.,Anthony, Diana,Rosair, Georgina M.,Houslay, Daniel M.,Huston, Elaine,Baillie, George S.,Klussmann, Enno,Houslay, Miles D.,Adams, David R.
supporting information; experimental part, p. 3331 - 3347 (2011/07/09)
Figure Presented. A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by i
