1054654-90-8

Basic information

• Product Name: C₃₃H₃₄N₄O₉Si
• CAS NO: 1054654-90-8
• Molecular Weight: 658.74
• Mol File: 1054654-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₄N₄O₉Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₄N₄O₉Si(1054654-90-8)
• EPA Substance Registry System: C₃₃H₃₄N₄O₉Si(1054654-90-8)

Safety Data

• Hazardous Substances Data: 1054654-90-8(Hazardous Substances Data)

Upstream product

• 175013-46-4 (2R,3R,3aS)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}3-hydroxy-2,3,3a,9a-tetrahydro-6H-furo[2’,3’:4,5]oxazole[3,2a]-pyrimidin-6-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 3736-77-4 2,2'-Anhydrouridine 
• 30777-83-4 2-(2-nitrobenzyloxy)isoindoline-1,3-dione 
• 179759-92-3 O-(2-nitrobenzyl)hydroxylamine 
• 185022-13-3 Imidazole-1-carboxylic acid (2R,3R,3aS,9aR)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-yl ester 

Relevant articles and documents

2'-Deoxy-2'-alkoxyaminouridines: Novel 2'-substituted uridines prepared by intramolecular nucleophilic ring opening of 2,2'-O-anhydrouridines

Natural and unnatural modified nucleosides and nucleotides play important roles in biology, medicine, and as biomedical research tools. Reported herein is an application of synthetic methodology developed for the stereo- and regiospecific introduction of structural modifications at the 2'-position of uridine nucleosides. A novel class of modified nucleosides, 2'-alkoxylamino-2'-deoxy uridines, are prepared by intramolecular nucleophilic addition of a 3'-tethered alkoxycarbamate nucleophile to the 2'-position with concomitant opening of a 2,2'-anhydrouridine.