105480-22-6 Usage
Structure
An imidazole derivative with a trifluoromethyl group attached to the alpha carbon
Applications
Used in the pharmaceutical industry for the synthesis of drugs and pharmaceutical products, as well as in research and development for the study of imidazole derivatives and their biological activities
Usage
Can be used as a building block in organic synthesis and medicinal chemistry for the creation of new compounds with specific properties.
Check Digit Verification of cas no
The CAS Registry Mumber 105480-22-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,4,8 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 105480-22:
(8*1)+(7*0)+(6*5)+(5*4)+(4*8)+(3*0)+(2*2)+(1*2)=96
96 % 10 = 6
So 105480-22-6 is a valid CAS Registry Number.
105480-22-6Relevant articles and documents
THERMAL CONDENSATION OF IMIDAZOLE WITH TRIFLUOROACETALDEHYDE
Fujii, Shozo,Maki, Yasuo,Kimoto, Hiroshi,Cohen, Louis A.
, p. 415 - 428 (2007/10/02)
The title condensation occurred readily at reflux (100 deg C) with the methyl hemiacetal of trifluoroacetaldehyde and provided 37.3percent of 4(5)-(1'-hydroxy-2',2',2'-trifluoroethyl)-imidazole as the major product, together with 8.8percent of 2-(1'-hydroxy-2',2',2'-trifluoroethyl)imidazole, 7.2percent of 2,4(5)-bis-(1'-hydroxy-2',2',2',-trifluoroethyl)imidazole and 0.4percent of the 4,5-bis-product. (Trifluoroacetyl)imidazoles were prepared by oxidation of these condensation products.Nitration and bromination of the condensation products gave the corresponding nitro- and bromoimidazoles, respectively.
