105480-29-3Relevant articles and documents
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Fujii,S.,Maki,Y.,Kimoto,H.
, p. 437 (1987)
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THERMAL CONDENSATION OF IMIDAZOLE WITH TRIFLUOROACETALDEHYDE
Fujii, Shozo,Maki, Yasuo,Kimoto, Hiroshi,Cohen, Louis A.
, p. 415 - 428 (2007/10/02)
The title condensation occurred readily at reflux (100 deg C) with the methyl hemiacetal of trifluoroacetaldehyde and provided 37.3percent of 4(5)-(1'-hydroxy-2',2',2'-trifluoroethyl)-imidazole as the major product, together with 8.8percent of 2-(1'-hydroxy-2',2',2'-trifluoroethyl)imidazole, 7.2percent of 2,4(5)-bis-(1'-hydroxy-2',2',2',-trifluoroethyl)imidazole and 0.4percent of the 4,5-bis-product. (Trifluoroacetyl)imidazoles were prepared by oxidation of these condensation products.Nitration and bromination of the condensation products gave the corresponding nitro- and bromoimidazoles, respectively.