10550-79-5Relevant articles and documents
A practical synthesis of (±)-α-isosparteine from a tetraoxobispidine core
Blakemore, Paul R.,Kilner, Colin,Norcross, Neil R.,Astles, Peter C.
, p. 4721 - 4724 (2005)
(Chemical Equation Presented) The title alkaloid was synthesized in racemic form from 3,7-diallyl-2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (7) by a regioselective diallylation reaction followed by double ring-closing olefin metathesis and exhaustive reduction. Tetraoxobispidine 7 was itself prepared in three simple operations from dimethyl malonate. The entire sequence to α-isosparteine was conducted on a multigram scale and proceeded without recourse to chromatography.
Synthesis and characterization of binuclear Co(II) complexes with bis(salen-type) ligands
R?is?nen, Minna T.,Korpi, Heikki,Sundberg, Markku R.,Savin, Alexander,Leskel?, Markku,Repo, Timo
, p. 203 - 209 (2013/02/23)
Two new, bridged bis(salen-type) ligand precursors, 1,1,3,3- tetrakis(salicylidene-3-iminopropyl)butylenediamine (I) and 1,1,3,3- tetra(salicylideneiminomethyl)propane (IV), were prepared by Schiff base condensation of salicylaldehyde with appropriate tet
Synthesis, Physicochemical and Pharmacological Properties of N,N′,N″, N?-Substituted Amides of 1,1,3,3- Propanetetracarboxylic Acid
Bezuglyi,Georgiyants,Perekhoda,Garnaya,Sych
, p. 475 - 477 (2007/10/03)
By condensation of symmetrical malonic acid diamides with dichloromethane (method a) and with paraform (method b) N,N′,N″,N?- substituted amides of 1,1,3,3-propanetetracarboxylic acid were synthesized. Better yields of the target products (68-80%) and the use of less toxic reagents indicate that method b is more feasible. The primary pharmacological screening revealed that the compounds obtained possess pronounced anticonvulsant activity at moderate toxicity.