1055195-11-3

Basic information

• Product Name: 2-(4-cyano-phenyl)-oxazole-4-carboxylic acid ethyl ester
• Synonyms: 2-(4-cyano-phenyl)-oxazole-4-carboxylic acid ethyl ester
• CAS NO: 1055195-11-3
• Molecular Weight: 242.234
• Mol File: 1055195-11-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-cyano-phenyl)-oxazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-cyano-phenyl)-oxazole-4-carboxylic acid ethyl ester(1055195-11-3)
• EPA Substance Registry System: 2-(4-cyano-phenyl)-oxazole-4-carboxylic acid ethyl ester(1055195-11-3)

Safety Data

• Hazardous Substances Data: 1055195-11-3(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 623-00-7 4-bromobenzenecarbonitrile 
• 3058-39-7 4-iodobenzonitrile 

Downstream Products

• 1055195-19-1 2-(4-cyanophenyl)-5-(4-methoxyphenyl)oxazole-4-carboxylic acid ethyl ester 
• 1248310-01-1 2-(4-cyano-phenyl)-oxazole-4-carboxylic acid 
• 1362690-80-9 ethyl 2-(4-methoxyphenyl)-5-phenyloxazole-4-carboxylate 
• 1362690-78-5 ethyl 2-(4-cyanophenyl)-5-phenyloxazole-4-carboxylate 

Relevant articles and documents

Radical C-H Arylation of Oxazoles with Aryl Iodides: Dppf as an Electron-Transfer Mediator for Cs2CO3

A radical C-H arylation reaction of oxazoles with (hetero)aryl iodides using Cs2CO3 as base/electron donor and 1,1′-bis(diphenylphosphino) ferrocene (dppf) as a catalytic SET mediator is reported. The overall reaction likely follows the general base-promoted homolytic aromatic substitution mechanism through a radical-chain pathway. DFT calculations suggest that dppf forms a complex with CsCO3-, enhancing its SET reducing ability to generate an aryl radical from ArI.

N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF

The present invention relates to compounds of general formula (I), wherein R1, LP, HetAr1, (Het)Ar2 and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

C-H bond arylations and benzylations on oxazol(in)es with a palladium catalyst of a secondary phosphine oxide

An air-stable, well-defined palladium complex derived from secondary phosphine oxide (SPO) (1-Ad)2P(O)H enabled efficient C-H bond functionalizations with ample scope, which set the stage for direct arylations and benzylations of (benz)oxazoles, as well as unprecedented palladium-catalyzed C-H bond arylations on nonaromatic oxazolines.