623-00-7Relevant articles and documents
Kinetics of oxidative ammonolysis of 4-bromo-o-xylene: V. Synthesis of 4-bromophthalonitrile
Bagirzade,Tagiev
, p. 1085 - 1090 (2014)
Oxidative ammonolysis of 4-bromo-o-xylene on a V-Sb-Bi-Zr/γ-Al 2O3 catalyst gives 74.82 mol % of 4-bromophthalonitrile at a high conversion of the starting xylene in a one-cycle process. The process with recirculation results in decreased number of by-products and contribution of deep oxidation and increased selectivity in 4-bromophthalonitrile up to 95.42-96.58%.
Dibromofluoromethylation of aryl Grignard reagents with dibromodifluoromethane in the presence of LiBr
Shiosaki, Masahiro,Inoue, Munenori
, p. 160 - 168 (2015)
The dibromofluoromethylation of aryl Grignard reagents bearing electron-withdrawing groups with dibromodifluoromethane (CF2Br2) proceeded in the presence of LiBr. The reaction gave the corresponding α,α-dibromo-α-fluorotoluene derivatives through halogen exchange reaction of intermediate difluorobenzyl anions.
Cyanation of arylboronic acids in aqueous solutions
Ma, Longle,Placzek, Michael S.,Hooker, Jacob M.,Vasdev, Neil,Liang, Steven H.
, p. 6597 - 6600 (2017)
A copper-mediated 11C-cyanation method employing arylboronic acids and [11C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic 11C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established 11C-cyanation methods that utilize aryl halide precursors.
Synthesis, Characterization, and Catalytic Study of Caffeine-Derived N-heterocyclic Carbene Palladium Complexes
Chen, Haiqun,Huynh, Han Vinh,Liu, Ziwei,Lu, Yuchen,Meng, Qi,Teng, Qiaoqiao,Yuan, Dan,Zhao, Yaru
, p. 161 - 168 (2022/02/07)
Homo- and heterodicarbene palladium complexes bearing caffeine-derived N-heterocyclic carbene ligands were synthesized and fully characterized by NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. The superior acidity of the alkylated ca
Method for dehydrating primary amide into nitriles under catalysis of cobalt
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Paragraph 0063-0065, (2021/06/21)
The invention provides a method for dehydrating primary amide into nitrile. The method comprises the following steps: mixing primary amide (II), silane, sodium triethylborohydride, aminopyridine imine tridentate nitrogen ligand cobalt complex (I) and a reaction solvent under the protection of inert gas, carrying out reacting at 60-100 DEG C for 6-24 hours, and post-treating reaction liquid to obtain a nitrile compound (III). According to the invention, an effective method for preparing nitrile compounds by cobalt-catalyzed primary amide dehydration reaction by using the novel aminopyridine imine tridentate nitrogen ligand cobalt complex catalyst is provided; and compared with existing methods, the method has the advantages of simple operation, mild reaction conditions, wide application range of reaction substrates, high selectivity, stable catalyst, high efficiency, and relatively high practical application value in synthesis.