105663-23-8Relevant articles and documents
Synthesis of non-THF analogs of acetogenin toward simplified mimics
Fujita, Daisuke,Ichimaru, Naoya,Abe, Masato,Murai, Masatoshi,Hamada, Takeshi,Nishioka, Takaaki,Miyoshi, Hideto
, p. 5775 - 5779 (2007/10/03)
Acetogenin analogs in which the bis-adjacent THF ring was replaced with an enantioselectively synthesized 1,2-cyclopentanediol bis-ether skeleton were synthesized to obtain simplified mimics, and their inhibitory effect on mitochondrial NADH-ubiquinone oxidoreductase (complex I) was examined. The results clearly demonstrate that the 1,2-cyclopentanediol bis-ether motif can substitute for the bis-THF ring while maintaining very potent inhibitory activity at the nanomolar level.
A one-step procedure for the monoacylation of symmetrical 1,2-diols
Clarke, Paul A.,Kayaleh, Nadim E.,Smith, Martin A.,Baker, James R.,Bird, Stephan J.,Chan, Chuen
, p. 5226 - 5231 (2007/10/03)
A series of lanthanide (III) salts have been shown to catalyze the monoacylation of symmetrical 1,2-diols by carboxylic acid anhydrides with surprisingly high selectivity.
Enzymatic Hydrolysis of (+/-)-trans-1,2-Diacetoxycycloalkanes. A Facile Route to Optically-active Cycloalkane-1,2-diols
Crout, David H. G.,Gaudet, Veronique S. B.,Laumen, Kurt,Schneider, Manfred P.
, p. 808 - 810 (2007/10/02)
The racemic title compounds were resolved conveniently into the enantiomers with high optical purities by enzymatic hydrolysis in the presence of porcine liver esterase.
