1056634-62-8

Basic information

• Product Name: ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate
• Synonyms: ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate;Benzoic acid, 4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, ethyl ester
• CAS NO: 1056634-62-8
• Molecular Formula: C₂₃H₂₄N₄O₃
• Molecular Weight: 404.46166
• Mol File: 1056634-62-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 635.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.244±0.06 g/cm3(Predicted)
• PKA: 5.24±0.40(Predicted)
• CAS DataBase Reference: ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate(1056634-62-8)
• EPA Substance Registry System: ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate(1056634-62-8)

Safety Data

• Hazardous Substances Data: 1056634-62-8(Hazardous Substances Data)

Usage

Description

Ethyl 4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate is a chemical compound that serves as an essential reactant in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which allows it to participate in chemical reactions to produce therapeutically relevant compounds.

Uses

Used in Pharmaceutical Industry:
Ethyl 4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate is used as a reactant in the synthesis of CYT387, a therapeutic agent used in the treatment of multiple myeloma. ethyl 4-(2-(4-MorpholinophenylaMino)pyriMidin-4-yl)benzoate plays a crucial role in the development of novel treatments for this type of cancer, contributing to the advancement of medical research and patient care.
In the synthesis of CYT387, ethyl 4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzoate is used as a key intermediate, enabling the creation of a drug with potential anti-cancer properties. Its involvement in the production of CYT387 highlights the importance of this compound in the pharmaceutical industry, particularly in the development of new cancer treatments.

Upstream product

• 2524-67-6 4-morpholino-4-yl-phenylamine 
• 499195-60-7 4-(4-carboethoxyphenyl)-2-chloropyrimidine 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 

Downstream Products

• 945749-71-3 4-(2-(4-(morpholinophenyl)amino)pyrimidin-4-yl)benzoic acid 
• 1056635-40-5 4-(2-(4-morpholinophenylamino)-5-methylpyrimidin-4-yl)-2-methoxybenzoic acid sodium salt 
• 1056634-68-4 Momelotinib 
• 1056635-49-4 N-(cyanomethyl)-2-methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide 

Relevant articles and documents

PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.