4334-88-7 Usage
Description
4-Ethoxycarbonylphenylboronic acid is an organic compound with the chemical formula C8H9BO4. It is a white to off-white powder and is known for its versatile reactivity in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
4-Ethoxycarbonylphenylboronic acid is used as a reactant involved in oxidative hydroxylation for the preparation of phenols. This application is crucial in the synthesis of various pharmaceutical compounds, as phenols are key building blocks in the development of drugs with diverse therapeutic properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Ethoxycarbonylphenylboronic acid is used as a reactant in homolytic aromatic substitution. This process allows for the introduction of new functional groups onto an aromatic ring, which can be vital for creating novel compounds with specific properties and applications.
Used in Cross-Coupling Reactions:
4-Ethoxycarbonylphenylboronic acid is utilized in cross-coupling reactions with α-bromocarbonyl compounds. These reactions are essential in the formation of carbon-carbon bonds, which are the backbone of many complex organic molecules, including those with potential applications in materials science and pharmaceuticals.
Used in Suzuki-Coupling Reactions:
In the context of Suzuki-coupling reactions, 4-Ethoxycarbonylphenylboronic acid is used as a reactant to form new carbon-carbon bonds with quinoline carboxylates. This reaction is significant in the synthesis of complex organic molecules, particularly those with potential applications in the development of new drugs and pharmaceuticals.
Used in Trifluoromethylation:
4-Ethoxycarbonylphenylboronic acid is also used in trifluoromethylation reactions, where it serves as a reactant to introduce a trifluoromethyl group (CF3) into a molecule. This functional group is known for its unique properties, such as increased lipophilicity and metabolic stability, which can enhance the pharmacokinetic and pharmacodynamic profiles of drug candidates.
Used in Carbometalation of Ynamides:
Lastly, 4-Ethoxycarbonylphenylboronic acid is employed in the carbometalation of ynamides, a reaction that involves the formation of a carbon-metal bond. This process is important in the synthesis of various organic compounds, including those with potential applications in the pharmaceutical and materials science industries.
Check Digit Verification of cas no
The CAS Registry Mumber 4334-88-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,3 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 4334-88:
(6*4)+(5*3)+(4*3)+(3*4)+(2*8)+(1*8)=87
87 % 10 = 7
So 4334-88-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BO4/c1-2-14-9(11)7-3-5-8(6-4-7)10(12)13/h3-6,12-13H,2H2,1H3
4334-88-7Relevant articles and documents
Sensitive thin-layer chromatography detection of boronic acids using alizarin
Duval, Florine,Van Beek, Teris A.,Zuilhof, Han
, p. 1751 - 1754 (2012)
A new method for the selective and sensitive detection of boronic acids on thin-layer chromatography plates is described. The plate is briefly dipped in an alizarin solution, allowed to dry in ambient air, and observed under 366nm light. Alizarin emits a bright yellow fluorescence only in the presence of a boronic acid.
A 4 - carboxyl preparation process of boric acid (by machine translation)
-
, (2017/08/28)
The invention discloses a 4 - carboxyl boric acid process. In order to to iodine benzoic acid as the raw material, by esterification reaction, sediment reaction and hydrolysis reaction to obtain the target product 4 - carboxyl boric acid, the total yield can reach 88.7%. The process route raw materials are cheap and easy to obtain, after-treatment is convenient, high yield, easy industrialized application. (by machine translation)
An Amine Functionalized Metal-Organic Framework as an Effective Catalyst for Conversion of CO2 and Biginelli Reactions
Verma, Ashish,De, Dinesh,Tomar, Kapil,Bharadwaj, Parimal K.
, p. 9765 - 9771 (2017/08/26)
A highly porous and thermally stable anionic Zn(II)-framework, {[(CH3)2NH2+]2[Zn3((μ3-O))(L)2(H2O)]·4DMF·2H2O}n (1), having exposed metal sites and pendant amine groups has been synthesized adopting the solvothermal technique. This anionic 3D framework showed two-fold interpenetration with 45.1% void volume. It has a 3,6-c binodal net with rare sit 3,6-conn topology. The metal bound aqua ligand could be easily removed along with the guest molecules in the lattice upon activation to afford the desolvated framework 1′. This produced exposed metal sites that, along with the pendant amine groups incorporated in the ligand, generated a coordination space in the framework to make it an outstanding heterogeneous catalyst for the chemical fixation of CO2 with various epoxides under atmospheric pressure and in the three-component Biginelli reaction with different aldehydes, ethyl acetoacetate, and urea to afford dihydropyrimidinones.
