732-80-9

Basic information

• Product Name: ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE
• Synonyms: RARECHEM AL BI 1217;4-Biphenylcarboxylic acid, 4'-methoxy-, ethyl ester (7CI,8CI);Ethyl 4'-methoxybiphen-4-ylcarboxylate;ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE;ETHYL 4'-METHOXY-4-BIPHENYLCARBOXYLATE;ETHYL 4'-METHOXYBIPHENYL-4-CARBOXYLATE;AKOS BAR-2336
• CAS NO: 732-80-9
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.3
• Product Categories: C12 to C63;Carbonyl Compounds;Esters
• Mol File: 732-80-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 102-108 °C(lit.)
• Boiling Point: 386.6 °C at 760 mmHg
• Flash Point: 162.8 °C
• Appearance: /
• Density: 1.099 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE(732-80-9)
• EPA Substance Registry System: ETHYL 4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXYLATE(732-80-9)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 732-80-9(Hazardous Substances Data)

Usage

Uses

Ethyl 4''-methoxybiphenyl-4-carboxylate

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 696-62-8 para-iodoanisole 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 22868-26-4 (p-methoxyphenyl)dimethylsilanol 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 64-17-5 ethanol 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 571903-64-5 4-(ethoxycarbonyl)phenylmagnesium chloride 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 496922-59-9 N-benzyl-N-(1-octynyl)-p-toluenesulfonamide 

Relevant articles and documents

Palladium-Catalyzed Three-Component Coupling of Ynamides

A palladium-catalyzed regioselective three-component coupling of ynamides was developed. The reaction proceeded smoothly to furnish the desired products when carried out at 70 °C in acetonitrile/water with potassium carbonate in the presence of 2.5 mol percent Pd2(dba)3·CHCl3 without a ligand. Various iodides and boronic acids were used in this reaction, and a carbon-carbon bond was formed with satisfactory regioselectivity from the ynamides.

Nickel-catalyzed cross-coupling of non-activated or functionalized aryl halides with aryl grignard reagents

Figure Presented New nickel complexes can efficiently catalyze cross-coupling of unactivated and deactivated aryl chlorides and fluorides with aryl Grignard reagents. The reaction can tolerate functional groups in aryl chlorides with or without the aid of additives, depending on the substrates (see scheme).

Efficient cobalt-catalyzed formation of unsymmetrical biaryl compounds and its application in the synthesis of a sartan intermediate

(Chemical Equation Presented) No prior preparation of the organometallic reagent is required in a cobalt-catalyzed coupling of two different aryl halides under mild conditions (see scheme). A broad spectrum of valuable biaryl compounds can be prepared in this way. Not only may a variety of reactive substituents be present, but heteroaryl halides and aryl triflates are also suitable substrates. DMF = N,N-dimethylformamide, FG = functional group.