288259-77-8

Basic information

• Product Name: ethyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoate
• Synonyms: ethyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoate
• CAS NO: 288259-77-8
• Molecular Weight: 412.572
• Mol File: 288259-77-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoate(288259-77-8)
• EPA Substance Registry System: ethyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoate(288259-77-8)

Safety Data

• Hazardous Substances Data: 288259-77-8(Hazardous Substances Data)

Upstream product

• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 288259-76-7 6-(3-bromophenyl)-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene 
• 2113-57-7 3-bromobiphenyl 
• 6223-78-5 2,5-dichloro-2,5-dimethyl hexane 

Relevant articles and documents

4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoi c acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor α agonists

Aromatic retinoids having a meta-substituted aromatic ring bridge, such as 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and its 3,5-diaryl-substituted 4,5-dihydroisoxazole analogue, function as retinoid receptor panagonists by activating both retinoic acid and retinoid X receptors to induce gene transcription, and thereby provide novel scaffolds for retinoid drug development. Both classes of these ligand-inducible transcription factors are involved in mediating the inhibitory effects of retinoids on cancer cell growth. (C) 2000 Elsevier Science Ltd. All rights reserved.