19578-70-2

Basic information

• Product Name: 2-Methyl-1-benzyloxybenzene
• Synonyms: (2-Methylphenyl)benzyl ether;2-(Benzyloxy)toluene;2-Methyl-1-benzyloxybenzene;Benzyl o-tolyl ether;Benzyl(2-methylphenyl) ether;o-Tolylbenzyl ether
• CAS NO: 19578-70-2
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.2604
• Mol File: 19578-70-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 301.7°Cat760mmHg
• Flash Point: 117.4°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 0.00186mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2-Methyl-1-benzyloxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1-benzyloxybenzene(19578-70-2)
• EPA Substance Registry System: 2-Methyl-1-benzyloxybenzene(19578-70-2)

Safety Data

• Hazardous Substances Data: 19578-70-2(Hazardous Substances Data)

Usage

General Description

2-Methyl-1-benzyloxybenzene, also known as o-anisyltoluene, is a chemical compound with the molecular formula C15H14O. It is a derivative of benzene with a methyl group and a benzyloxy group attached to different positions on the aromatic ring. 2-Methyl-1-benzyloxybenzene is used as a flavoring agent in the food industry and as a fragrance in perfumes and cosmetics. It is also used in the synthesis of pharmaceuticals and other organic compounds. 2-Methyl-1-benzyloxybenzene is considered to be relatively stable and non-reactive under normal conditions, but it should be handled with care due to its potential to cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C14H14O/c1-12-7-5-6-10-14(12)15-11-13-8-3-2-4-9-13/h2-10H,11H2,1H3

Upstream product

• 100-39-0 benzyl bromide 
• 4549-72-8 sodium o-cresolate 
• 100-44-7 benzyl chloride 
• 3235-09-4 potassium o-cresolate 
• 95-48-7 ortho-cresol 
• 108-88-3 toluene 
• 3204-68-0 benzyldimethylphenylammonium chloride 
• 100-51-6 benzyl alcohol 
• 533-18-6 2-methylphenyl acetate 
• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 5422-50-4 1-bromo-(2-methylphenoxymethyl)benzene 
• 22237-13-4 (4-ethoxyphenyl)boronic acid 
• 126747-14-6 4-cyanophenylboronic acid 
• 161950-10-3 4-chloro-3-methylbenzeneboronic acid 

Downstream Products

• 7294-84-0 2-(2-phenylethyl)phenol 
• 1208-45-3 2-benzyl-6-methylphenol 
• 29506-83-0 (2-methyl-4,6-dinitro-phenyl)-(4-nitro-benzyl)-ether 
• 5415-04-3 2-methyl-4-benzylphenol 
• 30090-90-5 2,4-Dibenzyl-6-methyl-phenol 
• 95-48-7 ortho-cresol 
• 108-88-3 toluene 
• 856381-01-6 1-(benzyloxy)-4-chloro-2-methylbenzene 
• 1570-64-5 2-methyl-4-chlorophenol 
• 343350-27-6 1-(4-nitrobenzyloxy)-2-methylbenzene 
• 112944-93-1 1-(4-chlorobenzyloxy)-2-methylbenzene 
• 500149-86-0 1-(4-methylbenzyloxy)-2-methylbenzene 
• 500149-85-9 1-(4-trifluoromethylbenzyloxy)-2-methylbenzene 
• 99-34-3 3,5-dinitrobenzoic acid 

Relevant articles and documents

Synergism of low energy microwave irradiation and solid-liquid phase transfer catalysis for selective alkylation of phenols to phenolic ethers

A 100% selectivity with an order of magnitude rate enhancement is obtained in the synthesis of phenolic ethers when synergistic combination of solid-liquid phase transfer catalysis and low energy microwave irradiation (MISL-PTC) is employed. As against conventional microwave heating with 600 W power input, the current work demonstrates that a low input of 40 W leads to remarkable enhancement in rates without any destruction of the catalyst.

An alternative route for boron phenoxide preparation from arylboronic acid and its application for C[sbnd]O bond formation

An efficient synthetic route to benzyl phenyl ether preparation has been successfully developed via a one-pot synthetic protocol utilizing a combination of arylboronic acids, hydrogen peroxide (H2O2), and benzyl halides. The whole procedure consists of two consecutive reactions, formation of boron phenoxide from arylboronic acids and its nucleophilic attack. A simple operation under mild conditions such as room-temperature ionic liquid (choline hydroxide), aerobic environment, and absence of metal- and base-catalysts has been employed. Expansion to utilize benzyl surrogates was also successfully accomplished.

Control of tandem isomerizations: Flow-assisted reactions of: O -lithiated aryl benzyl ethers

Tandem chemical changes are often difficult to control at will, because they proceed rapidly through multiple unstable reactive intermediates. It is desirable to develop a novel method for controlling such tandem changes to obtain desired products with high selectivity. Herein, we report a flow microreactor platform for controlling tandem isomerizations of o-lithiated aryl benzyl ethers based on precise residence time control.