112944-93-1

Basic information

• Product Name: Benzene, 1-[(4-chlorophenyl)methoxy]-2-methyl-
• CAS NO: 112944-93-1
• Molecular Formula: C14H13ClO
• Molecular Weight: 232.71
• Mol File: 112944-93-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(4-chlorophenyl)methoxy]-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(4-chlorophenyl)methoxy]-2-methyl-(112944-93-1)
• EPA Substance Registry System: Benzene, 1-[(4-chlorophenyl)methoxy]-2-methyl-(112944-93-1)

Safety Data

• Hazardous Substances Data: 112944-93-1(Hazardous Substances Data)

Upstream product

• 500149-85-9 1-(4-trifluoromethylbenzyloxy)-2-methylbenzene 
• 500149-86-0 1-(4-methylbenzyloxy)-2-methylbenzene 
• 19578-70-2 benzyl 2-methylphenyl ether 
• 343350-27-6 1-(4-nitrobenzyloxy)-2-methylbenzene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 95-48-7 ortho-cresol 

Downstream Products

• 500149-85-9 1-(4-trifluoromethylbenzyloxy)-2-methylbenzene 
• 500149-86-0 1-(4-methylbenzyloxy)-2-methylbenzene 
• 343350-27-6 1-(4-nitrobenzyloxy)-2-methylbenzene 
• 1570-64-5 2-methyl-4-chlorophenol 
• 95-48-7 ortho-cresol 

Relevant articles and documents

Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice

Ginger is one of the most commonly used fresh herbs and spices. Enterotoxigenic Escherichia coli heat-labile enterotoxin (LT)-induced diarrhea is the leading cause of infant death in developing countries. In this study, we demonstrated that ginger significantly blocked the binding of LT to cell-surface receptor GM1, resulting in the inhibition of fluid accumulation in the closed ileal loops of mice. Biological-activity-guided searching for active components showed that zingerone (vanillylacetone) was the likely active constituent responsible for the antidiarrheal efficacy of ginger. Further analysis of chemically synthesized zingerone derivatives revealed that compound 31 (2-[(4-methoxybenzyl)oxy]benzoic acid) significantly suppressed LT-induced diarrhea in mice via an excellent surface complementarity with the B subunits of LT. In conclusion, our findings provide evidence that ginger and its derivatives may be effective herbal supplements for the clinical treatment of enterotoxigenic Escherichia coli diarrhea.

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Benzyl and phenyl ethers can be easily obtained, with excellent yields, by the setting of Williamson's reaction in a heterogeneous medium: solid/liquid or liquid/liquid, or even with the use of microwaves, since the last two techniques do not need the use of a solvent.