6242-99-5

Basic information

• Product Name: Ethyl 4-(4-nitrophenyl)benzoate
• Synonyms: Ethyl 4-(4-nitrophenyl)benzoate;Ethyl 4'-nitro-[1,1'-biphenyl]-4-carboxylate;4'-Nitro-biphenyl-4-carboxylic acid ethyl ester
• CAS NO: 6242-99-5
• Molecular Formula: C₁₅H₁₃NO₄
• Molecular Weight: 271.26802
• Mol File: 6242-99-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 4-(4-nitrophenyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(4-nitrophenyl)benzoate(6242-99-5)
• EPA Substance Registry System: Ethyl 4-(4-nitrophenyl)benzoate(6242-99-5)

Safety Data

• Hazardous Substances Data: 6242-99-5(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(4-nitrophenyl)benzoate is a chemical compound that belongs to the family of benzoate esters. It is a yellow, crystalline solid with a molecular formula C15H13NO4 and a molecular weight of 271.26 g/mol. Ethyl 4-(4-nitrophenyl)benzoate is widely used in the field of organic chemistry as a reagent for various synthetic reactions. It is also utilized in the production of pharmaceuticals, fragrances, and other chemical products. The presence of the nitro group in its structure makes it an important intermediate for the synthesis of diverse organic compounds. As with all chemicals, proper handling and safety precautions should be observed when working with ethyl 4-(4-nitrophenyl)benzoate.

Upstream product

• 4334-88-7 p-ethoxycarbonylphenylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 64-17-5 ethanol 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 92-89-7 4'-nitro-biphenyl-4-carboxylic acid 

Relevant articles and documents

Palladium/tris(tert-butyl)phosphine-catalyzed Suzuki cross-couplings in the presence of water

Dipalladiumtris(dibenzylideneacetone)/tris(tert-butyl)phosphonium tetrafluoroborate/potassium fluoride dihydrate [Pd2(dba) 3/[HP(t-Bu)3]BF4/KF·2H2O] serves as a mild, robust, and user-friendly method for the efficient Suzuki cross-coupling of a diverse array of aryl and heteroaryl halides with aryl- and heteroarylboronic acids.

Polymer-Assisted Solution-Phase (PASP) Suzuki Couplings Employing an Anthracene-Tagged Palladium Catalyst

A general method for polymer-assisted solution-phase (PASP) Suzuki reactions employing a combination of anthracene-tagged palladium catalyst and anthracene-tagged boronic acid with a polymer-supported carbonate base is reported. The anthracene-tagged catalyst allows for the easy removal of the Pd catalyst along with the dissociated phosphine ligand and phosphine oxide byproducts by sequestration through a chemoselective Diels-Alder reaction with a maleimide resin. The polymer-supported carbonate base facilitates the removal of excess boronic acid and the borane-containing byproducts present at the end of the coupling reaction. The Suzuki coupling reaction can be efficiently conducted by using combinations of the anthracene-tagged Pd catalyst, polymer-supported carbonate base, and anthracene-tagged boronic acid to yield the desired product in high purity and yield without the use of chromatography.