1056877-13-4

Basic information

• Product Name: 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde
• Synonyms: 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde;1,5-Naphthyridine-4-carboxaldehyde, 3-methoxy-;3-METHOXY-1,5-NAPHTHYRIDINE-4-CARBALDEHYDE(WXC06034)
• CAS NO: 1056877-13-4
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18272
• Mol File: 1056877-13-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde(1056877-13-4)
• EPA Substance Registry System: 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde(1056877-13-4)

Safety Data

• Hazardous Substances Data: 1056877-13-4(Hazardous Substances Data)

Usage

General Description

3-Methoxy-[1,5]naphthyridine-4-carbaldehyde is a chemical compound that belongs to the naphthyridine family. It is characterized by the presence of a methoxy group at the 3-position and an aldehyde group at the 4-position on the naphthyridine ring. 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde is mainly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and biologically active molecules. It possesses potential biological activities and has been studied for its anti-inflammatory and antiviral properties. Additionally, 3-Methoxy-[1,5]naphthyridine-4-carbaldehyde has also been investigated for its potential use in the development of novel therapeutic agents and drug discovery.

Upstream product

• 1056877-12-3 [(E)-2-(3-methoxy-[1,5]-naphthyridin-4-yl)-vinyl]-dimethyl-amine 
• 1192255-92-7 (3-methoxy[1,5]naphthyridin-4-yl)methanol 
• 50720-12-2 3-bromo-5-methoxypyridine 
• 1045858-10-3 tert-butyl 5-methoxy-4-methylpyridin-3-ylcarbamate 
• 1185094-00-1 3-amino-5-methoxy-4-methylpyridine hydrochloride 
• 893566-31-9 3-methoxy-4-methyl[1,5]naphthyridine 
• 893566-34-2 (3-methoxy[1,5]naphthyridin-4-yl)methyl bromide 
• 64436-92-6 3-amino-5-methoxypyridine 
• 342603-10-5 tert-butyl 5-methoxypyridin-3-ylcarbamate 

Downstream Products

• 1056877-14-5 3-hydroxy[1,5]naphthyridine-4-carbaldehyde 
• 1192256-10-2 3-descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl-(1-((3-hydroxy-[1,5]naphthyridin-4-yl)-methyl)-azetidin-3-yl)-imino)-erythromycin A tosylate 

Relevant articles and documents

Process development of a novel azetidinyl ketolide antibiotic

Process development and the multikilogram synthesis of a novel azetidinyl ketolide antibiotic is described. Starting with clarithromycin, the eight-step synthesis features several telescoped operations and direct isolations, which results in a significant improvement in throughput and a major reduction in solvent usage and waste stream volume over the first scale-up campaign. Particular highlights of this effort include the development of an efficient synthesis of 3-hydroxy-1,5-naphthyridine-4-carbaldehyde via a Skraup process and engineering a robust final API synthesis. We also discovered a crystalline monotosylate salt that addressed significant formulation and degradation issues experienced when using the noncrystalline freebase.

MACROLIDES

The invention relates to compounds of Formula (I): wherein R1, R2 and X are as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of Formula (I).