1056877-14-5

Basic information

• Product Name: 3-hydroxy-1,5-naphthyridine-4-carbaldehyde
• Synonyms: 3-hydroxy-1,5-naphthyridine-4-carbaldehyde;3-Hydroxy-1,5-naphthyridine-4-carboxaldehyde;1,5-Naphthyridine-4-carboxaldehyde, 3-hydroxy-;3-HYDROXY-1,5-NAPHTHYRIDINE-4-CARBALDEHYDE(WXC06035)
• CAS NO: 1056877-14-5
• Molecular Formula: C₉H₆N₂O₂
• Molecular Weight: 174.15614
• Mol File: 1056877-14-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.450
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-hydroxy-1,5-naphthyridine-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-1,5-naphthyridine-4-carbaldehyde(1056877-14-5)
• EPA Substance Registry System: 3-hydroxy-1,5-naphthyridine-4-carbaldehyde(1056877-14-5)

Safety Data

• Hazardous Substances Data: 1056877-14-5(Hazardous Substances Data)

Usage

General Description

3-hydroxy-1,5-naphthyridine-4-carbaldehyde is a chemical compound with a molecular formula C12H7NO2. It is a naphthyridine derivative with a hydroxyl and an aldehyde functional group attached to the structure. 3-hydroxy-1,5-naphthyridine-4-carbaldehyde has potential applications in pharmaceutical and agrochemical industries due to its unique chemical structure and properties. It can be used as a building block in synthesis of various bioactive molecules, such as antiviral or antibacterial agents. Additionally, it has been studied for its potential as a fluorescent probe for detecting metal ions, particularly copper ions. Overall, 3-hydroxy-1,5-naphthyridine-4-carbaldehyde is a versatile compound with potential use in various research and commercial applications.

Upstream product

• 1056877-13-4 3-methoxy-1,5-naphthyridine-4-carbaldehyde 
• 1056877-12-3 [(E)-2-(3-methoxy-[1,5]-naphthyridin-4-yl)-vinyl]-dimethyl-amine 
• 342603-10-5 tert-butyl 5-methoxypyridin-3-ylcarbamate 
• 64436-92-6 3-amino-5-methoxypyridine 
• 1192255-92-7 (3-methoxy[1,5]naphthyridin-4-yl)methanol 
• 893566-34-2 (3-methoxy[1,5]naphthyridin-4-yl)methyl bromide 
• 893566-31-9 3-methoxy-4-methyl[1,5]naphthyridine 
• 1185094-00-1 3-amino-5-methoxy-4-methylpyridine hydrochloride 
• 1045858-10-3 tert-butyl 5-methoxy-4-methylpyridin-3-ylcarbamate 
• 50720-12-2 3-bromo-5-methoxypyridine 

Downstream Products

• 1192256-10-2 3-descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl-(1-((3-hydroxy-[1,5]naphthyridin-4-yl)-methyl)-azetidin-3-yl)-imino)-erythromycin A tosylate 

Relevant articles and documents

Process development of a novel azetidinyl ketolide antibiotic

Process development and the multikilogram synthesis of a novel azetidinyl ketolide antibiotic is described. Starting with clarithromycin, the eight-step synthesis features several telescoped operations and direct isolations, which results in a significant improvement in throughput and a major reduction in solvent usage and waste stream volume over the first scale-up campaign. Particular highlights of this effort include the development of an efficient synthesis of 3-hydroxy-1,5-naphthyridine-4-carbaldehyde via a Skraup process and engineering a robust final API synthesis. We also discovered a crystalline monotosylate salt that addressed significant formulation and degradation issues experienced when using the noncrystalline freebase.

MACROLIDES

The invention relates to compounds of Formula (I): wherein R1, R2 and X are as defined herein. The invention also relates to pharmaceutical compositions and methods of treating bacterial infections using compounds of Formula (I).