1057319-20-6

Basic information

• Product Name: 2-chloro-5-fluoroisonicotinonitrile
• Synonyms: 2-chloro-5-fluoroisonicotinonitrile
• CAS NO: 1057319-20-6
• Molecular Formula: C₆H₂ClFN₂
• Molecular Weight: 156.5448832
• Mol File: 1057319-20-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-5-fluoroisonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-fluoroisonicotinonitrile(1057319-20-6)
• EPA Substance Registry System: 2-chloro-5-fluoroisonicotinonitrile(1057319-20-6)

Safety Data

• Hazardous Substances Data: 1057319-20-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluoroisonicotinonitrile is a chemical compound with the molecular formula C6H2ClFN2. It is a nitrile derivative of isonicotinic acid and contains a chlorine and fluorine substituent on the 2 and 5 positions of the pyridine ring, respectively. 2-chloro-5-fluoroisonicotinonitrile is used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceuticals, including antiviral and antitumor drugs. It is also employed in the production of agrochemicals and other specialty chemicals. Due to its reactivity and potential health hazards, handling and usage of 2-chloro-5-fluoroisonicotinonitrile should be carried out with appropriate safety precautions and under controlled conditions.

Upstream product

• 884494-49-9 2-chloro-5-fluoro-4-iodopyridine 
• 544-92-3 copper(I) cyanide 
• 31301-51-6 2-chloro-5-fluoropyridine 
• 511522-70-6 2-chloro-4,5-difluoropyridine 

Downstream Products

• 924651-77-4 tert-butyl (2-chloro-5-fluoropyridin-4-yl)methylcarbamate 

Relevant articles and documents

FGFR4 inhibitor and preparation method and application thereof

The invention relates to an FGFR4 inhibitor and a preparation method and application thereof, in particular to a medicine composition of the FGFR4 inhibitor with a structure shown in the formula (I).The medicine composition has a high inhibiting effect on FGFR4 kinase activity, and can be widely applied to preparation of medicine for treating cancers including the liver cancer, the stomach cancer, the prostatic cancer, the skin cancer, the ovarian cancer, the lung cancer, the breast cancer and the colon cancer.

N-(PYRIDIN-4-YL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer’s disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.