884494-49-9

Basic information

• Product Name: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE
• Synonyms: 2-Chloro-5-Fluoro-4-Iodopyridine98%
• CAS NO: 884494-49-9
• Molecular Formula: C₅H₂ClFIN
• Molecular Weight: 257.43
• Product Categories: Fluorine series
• Mol File: 884494-49-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 242℃
• Flash Point: 100℃
• Appearance: /
• Density: 2.129
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.37±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE(884494-49-9)
• EPA Substance Registry System: 2-CHLORO-5-FLUORO-4-IODOPYRIDINE(884494-49-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 884494-49-9(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-fluoro-4-iodopyridine is a chemical compound with the molecular formula C5H2ClFIN. It is a derivative of pyridine, containing chlorine, fluorine, and iodine atoms attached to the pyridine ring. 2-CHLORO-5-FLUORO-4-IODOPYRIDINE is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in organic reactions and in the development of new chemical compounds. 2-Chloro-5-fluoro-4-iodopyridine is a valuable chemical reagent with potential applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C5H2ClFIN/c6-5-1-4(8)3(7)2-9-5/h1-2H

Upstream product

• 31301-51-6 2-chloro-5-fluoropyridine 

Downstream Products

• 1057319-20-6 2-chloro-5-fluoroisonicotinonitrile 
• 1184931-53-0 2-[(2-chloro-5-fluoro-4-pyridinyl)amino]-N-methylbenzamide 
• 1602485-98-2 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1602486-04-3 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfanyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1602486-05-4 (2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methanol 
• 1602486-06-5 N-[4-(chloromethyl)pyridin-2-yl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine 
• 1602485-99-3 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(methylsulfonyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1602486-09-8 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-methyl-4-[(methylsulfanyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1602486-12-3 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-fluoro-4-[(methylsulfanyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1602486-14-5 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(methylsulfanyl)methyl]-6-(trifluoromethyl)pyridin-2-yl}pyridin-2-amine 
• 1602486-02-1 6-(difluoromethyl)-N-(5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)-4-((methylsulfonyl)methyl)pyridin-2-amine 
• 1602486-03-2 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridine 
• 1610358-85-4 (rac)-5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{6-fluoro-4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine 
• 1610358-87-6 (rac)-2,2,2-trifluoro-N-{[(2-fluoro-6-{[5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl]amino}pyridin-4-yl)methyl](methyl)oxido-λ⁶-sulfanylidene}acetamide 

Relevant articles and documents

FUSED BICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE

Fused bicyclic compounds and uses thereof in medicine. In particular, provided are fused bicyclic compounds used as ASK1 active regulator and and use of the compounds in the manufacture of a drug for treating a disease regulated by ASK1. Further provided are a pharmaceutical composition and a method of treating a disease regulated by ASK1 comprising administering the compounds or pharmaceutical composition thereof.

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

POLYSUBSTITUTED PYRIDINE COMPOUND, PREPARATION METHOD, USE AND PHARMACEUTICAL COMPOSITION

The present invention provides a polysubstituted pyridine compound of Formula I, a preparation method, a use and a pharmaceutical composition thereof. The polysubstituted pyridine compound of Formula I according to the present invention has an excellent anti-tumor effect, can inhibit various cell kinases simultaneously, has significantly excellent pharmacokinetic characteristics, and is very suitable for oral and intravenous administration. The pharmaceutical composition according to the present invention can be useful for treating tumors and cancers.