106079-12-3

Basic information

• Product Name: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-
• CAS NO: 106079-12-3
• Molecular Formula: C11H11ClO
• Molecular Weight: 194.661
• Mol File: 106079-12-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-(106079-12-3)
• EPA Substance Registry System: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-(106079-12-3)

Safety Data

• Hazardous Substances Data: 106079-12-3(Hazardous Substances Data)

Upstream product

• 4426-11-3 cyclobutanecarbonitrile 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 28049-61-8 1-(4-chlorophenyl)cyclobutanecarbonitrile 

Downstream Products

• 858645-29-1 (R)-N-(1-(4-chlorophenyl)cyclobutanemethylene)-t-butanesulfinamide 
• 1359840-94-0 tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-cyanophenyl)ethyl}carbamate 
• 1359840-93-9 3-{2-amino-1-[1-(4-chlorophenyl)cyclobutyl]ethyl}benzonitrile 
• 1359840-92-8 3-{1-[1-(4-chlorophenyl)cyclobutyl]-2-nitroethyl}benzonitrile 
• 1359840-90-6 1-chloro-4-{1-[(E)-2-nitroethenyl]cyclobutyl}benzene 
• 1359840-32-6 tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-[3-({methyl[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}methyl)phenyl]ethyl}carbamate 
• 1359840-96-2 tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate 
• 1359840-95-1 tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-formylphenyl)ethyl}carbamate 
• 229639-54-7 (R)-(+)-N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine 
• 229639-57-0 (S)-(-)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine 
• 229639-56-9 (R)-N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}amine 
• 259729-89-0 [1-[1-(4-Chloro-phenyl)-cyclobutyl]-meth-(E)-ylidene]-methyl-amine 
• 1240048-89-8 1-[1-(4-chlorophenyl)cyclobutyl]-2,3,4,9-tetrahydro-1H-b-carboline 
• 1240048-69-4 6-(1-(4-chlorophenyl)cyclobutyl)-5-nitropiperidin-2-one 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE GLYCINE TRANSPORTER 1

The present invention relates to heterocyclic compounds of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising such heterocyclic compounds, and the use of such heterocyclic compounds for the manufacture of a medicament for inhibiting the glycine transporter GIyT1.

First application of tunable alkyl or aryl sulfinamides to the stereoselective synthesis of a chiral amine: asymmetric synthesis of (R)-didesmethylsibutramine ((R)-DDMS) using (R)-triethylmethylsulfinamide ((R)-TESA).

A highly diastereoselective addition of i-BuLi to a triethylmethylsulfinamide derived aldimine was used as the key step in the first asymmetric synthesis of (R)-didesmethylsibutramine, a metabolite of sibutramine for the potential treatment of CNS disorders. [reaction: see text]