259729-89-0

Basic information

• Product Name: Methanamine, N-[[1-(4-chlorophenyl)cyclobutyl]methylene]-
• CAS NO: 259729-89-0
• Molecular Formula: C12H14ClN
• Molecular Weight: 207.703
• Mol File: 259729-89-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanamine, N-[[1-(4-chlorophenyl)cyclobutyl]methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanamine, N-[[1-(4-chlorophenyl)cyclobutyl]methylene]-(259729-89-0)
• EPA Substance Registry System: Methanamine, N-[[1-(4-chlorophenyl)cyclobutyl]methylene]-(259729-89-0)

Safety Data

• Hazardous Substances Data: 259729-89-0(Hazardous Substances Data)

Upstream product

• 28049-61-8 1-(4-chlorophenyl)cyclobutanecarbonitrile 
• 4426-11-3 cyclobutanecarbonitrile 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 74-89-5 methylamine 
• 106079-12-3 1-(4-chlorophenyl)-cyclobutanecarboxaldehyde 

Downstream Products

• 229639-54-7 (R)-(+)-N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine 

Relevant articles and documents

First asymmetric synthesis of (R)-desmethylsibutramine

A catalytic enantioselective addition of iBuLi to aldimine 3 derived from methyl amine and 1-(4-chlorophenyl) cyclobutanecarboxaldehyde is used as the key step in the asymmetric synthesis of (R)-desmethylsibutramine, a single enantiomer version of a pharmacologically active metabolite of anti-obesity drug sibutramine (Meridia).