1062608-28-9

Basic information

• Product Name: 2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one
• Synonyms: 2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one
• CAS NO: 1062608-28-9
• Molecular Weight: 450.283
• Mol File: 1062608-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one(1062608-28-9)
• EPA Substance Registry System: 2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one(1062608-28-9)

Safety Data

• Hazardous Substances Data: 1062608-28-9(Hazardous Substances Data)

Upstream product

• 133430-98-5 2-bromo-4-iodo-phenol 
• 540-38-5 p-Iodophenol 
• 1062616-69-6 4-(3-bromo-phenylethynyl)-2-cyclopropyl-1-difluoromethoxy-benzene 
• 1062615-44-4 2-cyclopropyl-1-difluoromethoxy-4-ethynyl-benzene 
• 1062615-36-4 2-bromo-1-difluoromethoxy-4-iodo-benzene 
• 1062616-71-0 1-(3-bromo-phenyl)-2-(3-cyclopropyl-4-difluoromethoxy-phenyl)-ethane-1,2-dione 
• 22661-87-6 1-methylguanidine hydrochloride 

Downstream Products

• 1062608-30-3 (R)-2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one 
• 1062608-33-6 (S)-2-amino-5-(3-bromo-phenyl)-5-(3-cyclopropyl-4-difluoromethoxy-phenyl)-3-methyl-3,5-dihydro-imidazol-4-one 

Relevant articles and documents

AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ?-SECRETASE INHIBITORS

The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.