22661-87-6 Usage
Description
Methylguanidine hydrochloride, also known as N-Methylguanidine, is an alkylated guanidine derivative that exhibits inhibitory action against trypsin catalysis. It is characterized by its white to off-white powdery appearance and has been found to inhibit the metabolism of certain hepatic drugs mediated by cytochrome P450 protein in human liver microsome and hepatocyte.
Uses
Used in Pharmaceutical Industry:
Methylguanidine hydrochloride is used as an inhibitor for [application type] due to its ability to inhibit trypsin catalysis and metabolism of certain hepatic drugs. This makes it a valuable compound in the development of drugs targeting specific metabolic pathways and enzyme interactions.
Used in Research and Development:
In the field of research and development, Methylguanidine hydrochloride serves as a crucial tool for studying the mechanisms of trypsin inhibition and the role of cytochrome P450 protein in drug metabolism. Its use in this context aids in understanding the complex interactions between enzymes and their substrates, potentially leading to the discovery of novel therapeutic strategies.
Used in Diagnostic Applications:
Methylguanidine hydrochloride can be employed as a diagnostic agent for [application reason] in the assessment of liver function and the activity of cytochrome P450 proteins. Its inhibitory properties allow for the evaluation of enzyme activity levels, which can be indicative of various liver-related conditions and drug metabolism efficiency.
Check Digit Verification of cas no
The CAS Registry Mumber 22661-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,6,6 and 1 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 22661-87:
(7*2)+(6*2)+(5*6)+(4*6)+(3*1)+(2*8)+(1*7)=106
106 % 10 = 6
So 22661-87-6 is a valid CAS Registry Number.
InChI:InChI=1/C2H7N3.ClH/c1-2(3)5-4;/h5H,1,3-4H2;1H
22661-87-6Relevant articles and documents
PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
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, (2010/03/02)
The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.
SIMPLE AMIDINIUM CARBOXYLATES - AN MO TREATMENT OF MOLECULAR GEOMETRY AND ELECTRONIC STRUCTURE
Krechl, Jiri,Boehm, Stanislav,Smrckova, Svatava,Kuthan, Josef
, p. 673 - 683 (2007/10/02)
Carboxylates of amidines (I,II), substituted guanidine (III) and iso(thio)ureas (IV,V) were prepared.Nonempirical quantum chemical treatment of the electronic structure of simple compounds I-V, based on total molecular geometry optimization, their preparation and physicochemical data are reported.Interaction between the two amidinium nitrogens and carboxylate oxygens is mediated by hydrogen bonds and alternation of charge distribution.