1063631-10-6

Basic information

• Product Name: benzyl 3-acetyl-4-methyl-1H-pyrrole-2-carboxylate
• Synonyms: benzyl 3-acetyl-4-methyl-1H-pyrrole-2-carboxylate
• CAS NO: 1063631-10-6
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.289
• Mol File: 1063631-10-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 454.6±45.0 °C(Predicted)
• Density: 1.201±0.06 g/cm3(Predicted)
• CAS DataBase Reference: benzyl 3-acetyl-4-methyl-1H-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 3-acetyl-4-methyl-1H-pyrrole-2-carboxylate(1063631-10-6)
• EPA Substance Registry System: benzyl 3-acetyl-4-methyl-1H-pyrrole-2-carboxylate(1063631-10-6)

Safety Data

• Hazardous Substances Data: 1063631-10-6(Hazardous Substances Data)

Upstream product

• 7299-55-0 pent-3-yn-2-one 
• 41995-26-0 benzyl isocyanoacetate 
• 14447-18-8 benzyl 2-cyanoacetate 

Downstream Products

• 1063631-12-8 4,3'-diacetyl-5,5'-dibenzyloxycarbonyl-3,4'-dimethyl-2,2'-dipyrrylmethane 
• 5594-29-6 3,3'-[7,12-bis-(1-hydroxy-ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-diyl]-bis-propionic acid dimethyl ester 

Relevant articles and documents

Total synthesis of hematoporphyrin and protoporphyrin: A conceptually new approach

The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2. Coupling of the two fragments leads directly to porphyrin 3 without the need of an oxidizing agent. The new methodology is well suited for the synthesis of protoporphyrin IX derivatives on a multi 100 g scale in good quality without the need for chromatography. Furthermore, these preparations are completely free of any contaminant of animal origin, which represents a real improvement in the manufacturing of protoporphyrin IX derivatives.

Process For Preparing Porphyrin Derivatives, Such As Protoporphyrin (IX) And Synthesis Intermediates

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R′b is as defined above for (I), and a dipyrromethane of formula (III): in which R″ is as defined in claim 1, and also the compounds of formula (III).