5594-29-6

Basic information

• Product Name: HEMATOPORPHYRIN IX DIMETHYL ESTER
• Synonyms: HEMATOPORPHYRIN IX DIMETHYL ESTER;DIMETHYL-8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONATE;haematoporphyrin IX dimethyl ester
• CAS NO: 5594-29-6
• Molecular Formula: C₃₆H₄₂N₄O₆
• Molecular Weight: 626.74
• Product Categories: Natural Porphyrins and Derivitives;Porphyrins
• Mol File: 5594-29-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: HEMATOPORPHYRIN IX DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: HEMATOPORPHYRIN IX DIMETHYL ESTER(5594-29-6)
• EPA Substance Registry System: HEMATOPORPHYRIN IX DIMETHYL ESTER(5594-29-6)

Safety Data

• Hazardous Substances Data: 5594-29-6(Hazardous Substances Data)

Usage

Uses

Hematoporphyrin IX Dimethyl Ester is a hematoporphyrin derivative used for research.

Upstream product

• 1063631-12-8 4,3'-diacetyl-5,5'-dibenzyloxycarbonyl-3,4'-dimethyl-2,2'-dipyrrylmethane 
• 1063631-14-0 4,3'-diacetyl-3,4'-dimethyl-5,5'-diiodo-2,2'-dipyrrylmethane 
• 1063631-10-6 3-acetyl-2-benzyloxycarbonyl-4-methyl-1H-pyrrole 
• 2386-26-7 ethyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate 
• 7299-55-0 pent-3-yn-2-one 
• 2386-27-8 benzyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate 
• 20303-31-5 benzyl 4-(2-methoxycarbonylethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 54605-86-6 3-(5-benzyloxycarbonyl-2-bromomethyl-4-methyl-pyrrol-3-yl)-propionic acid methyl ester 
• 992-36-9 dibenzyl 3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 19996-71-5 5-acetoxymetyl-4-acetyl-2-benzyloxycarbonyl-3-methyl-1H-pyrrole 
• 809-27-8 4,4'-bis-(2-methoxycarbonyl-ethyl)-3,3'-dimethyl-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid 
• 4792-10-3 3-{5-Formyl-2-[5-formyl-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester 
• 1063631-13-9 C₁₇H₁₈N₂O₆ 
• 186581-53-3 diazomethane 

Relevant articles and documents

Stereoselective synthesis of the nitric-reducing cofactor herme d1 from hematoporphyrin

The nitrite-reducing cofactor heme d1 has been synthesized in a few synthetic steps, starting from readily accessible hematoporphyrin dimethyl ester (rac-4a). A single-crystal structure analysis of the synthesized target molecule rac-10a unequivocally established the constitution and the relative configuration of heme d1 (3).

Total synthesis of hematoporphyrin and protoporphyrin: A conceptually new approach

The total synthesis of protoporphyrin IX and its disodium salt using a new alternative method to the classical MacDonald condensation is reported. The key step is the reaction of the new unsymmetrical diiodo dipyrrylmethane 1 with the known dipyrrylmethane 2. Coupling of the two fragments leads directly to porphyrin 3 without the need of an oxidizing agent. The new methodology is well suited for the synthesis of protoporphyrin IX derivatives on a multi 100 g scale in good quality without the need for chromatography. Furthermore, these preparations are completely free of any contaminant of animal origin, which represents a real improvement in the manufacturing of protoporphyrin IX derivatives.