4792-10-3

Basic information

• Product Name: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester
• CAS NO: 4792-10-3
• Molecular Formula: C21H26N2O6
• Molecular Weight: 402.447
• Mol File: 4792-10-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester(4792-10-3)
• EPA Substance Registry System: 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester(4792-10-3)

Safety Data

• Hazardous Substances Data: 4792-10-3(Hazardous Substances Data)

Usage

General Description

The chemical 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester is a compound with a complex structure containing pyrrole, propanoic acid, methylene, formyl, and methyl groups. It is a dimethyl ester, meaning it has two ester functional groups. 1H-Pyrrole-3-propanoic acid, 2,2'-methylenebis[5-formyl-4-methyl-, dimethyl ester may have potential applications in the pharmaceutical or chemical industries due to its unique structure and properties. It can be used as a building block for the synthesis of more complex organic molecules and may have biological activity that could be of interest for drug development. However, further research is needed to fully understand its potential uses and effects.

Upstream product

• 30103-05-0 5,5'-bis(tert-butoxycarbonyl)-4,4'-dimethyl-3,3-bis(2-(methoxycarbonyl)ethyl)-2,2'-dipyrrylmethane 
• 149-73-5 trimethyl orthoformate 
• 54605-86-6 3-(5-benzyloxycarbonyl-2-bromomethyl-4-methyl-pyrrol-3-yl)-propionic acid methyl ester 
• 859-38-1 benzyl 5-acetoxymethyl-4-(2-methoxycarbonylethyl)-3-methylpyrrole-2-carboxylate 
• 30089-44-2 tert-butyl 5-acetoxymethyl-4-(2-methoxycarbonylethyl)-3-methyl-pyrrole-2-carboxylate 
• 60024-89-7 4-(2-methoxycarbonylethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 992-36-9 dibenzyl 3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 20303-31-5 benzyl 4-(2-methoxycarbonylethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 802-52-8 3,3'-dimethoxycarbonylethyl-4,4'-dimethyl-2,2'-dipyrromethane 
• 809-27-8 4,4'-bis-(2-methoxycarbonyl-ethyl)-3,3'-dimethyl-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid 
• 76-05-1 trifluoroacetic acid 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 26280-00-2 biliverdin IX_γ dimethyl ester 
• 79760-31-9 γ-benzoyloxy-2,4-di(2-chloroethyl)-6,7-di(2-methoxycarbonylethyl)-1,3,5,8-tetramethylporphyrin 
• 79760-30-8 Benzoic acid (5E,10Z,14Z,19Z)-13,18-bis-(2-hydroxy-ethyl)-3,7-bis-(2-methoxycarbonyl-ethyl)-2,8,12,17-tetramethyl-porphyrin-5-yl ester 
• 79760-29-5 2,4-bis(2-acetoxyethyl)-γ-benzoyloxy-6,7-bis(2-methoxycarbonylethyl)-1,3,5,8-tetramethylporphyrin 
• 10591-31-8 2,4-diacetyl-6,7-bis<2-(methoxycarbonyl)ethyl>-1,3,5,8-tetramethylporphyrin 
• 5594-29-6 3,3'-[7,12-bis-(1-hydroxy-ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-diyl]-bis-propionic acid dimethyl ester 
• 53872-58-5 3-(2-chloroethyl)-8,13,17-tris(2-methoxycarbonylethyl)-2,7,12,18-tetramethylporphyrin 
• 42607-18-1 harderoporphyrinogen-III 
• 30783-27-8 3-vinyl-2,7,12,18-tetramethylporphyrin-8,13,17-tripropionic acid 
• 553-12-8 protoporphyrin IX 
• 16132-39-1 5'-formyl-3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethylpyrromethane-5-carboxylic acid 
• 26019-74-9 5,5'-diformyl-4,4'-dimethyl-3,3'-bis-(methoxycarbonylethyl)-2,2'-dipyrryl ketone 
• 99602-71-8 5,5'-diformyl-3,3'-bis(2-benzyloxycarbonylethyl)-4,4'-dimethyl-2,2'-methylenedipyrrole 
• 144629-74-3 trans-4,4'-bis<2,8-diethyl-13,17-bis<2-(methoxycarbonyl)ethyl>-3,7,12,18-tetramethylporphyrin-5-yl>stilbene 

Relevant articles and documents

Corrole-Substituted Fluorescent Heme Proteins

Although fluorescent proteins have been utilized for a variety of biological applications, they have several optical limitations, namely weak red and near-infrared emission and exceptionally broad (>200 nm) emission profiles. The photophysical properties of fluorescent proteins can be enhanced through the incorporation of novel cofactors with the desired properties into a stable protein scaffold. To this end, a fluorescent phosphorus corrole that is structurally similar to the native heme cofactor is incorporated into two exceptionally stable heme proteins: H-NOX from Caldanaerobacter subterraneus and heme acquisition system protein A (HasA) from Pseudomonas aeruginosa. These yellow-orange emitting protein conjugates are examined by steady-state and time-resolved optical spectroscopy. The HasA conjugate exhibits enhanced fluorescence, whereas emission from the H-NOX conjugate is quenched relative to the free corrole. Despite the low fluorescence quantum yields, these corrole-substituted proteins exhibit more intense fluorescence in a narrower spectral profile than traditional fluorescent proteins that emit in the same spectral window. This study demonstrates that fluorescent corrole complexes are readily incorporated into heme proteins and provides an inroad for the development of novel fluorescent proteins.

The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX

During heme biosynthesis the oxygen-independent coproporphyrinogen III oxidase HemN catalyzes the oxidative decarboxylation of the two propionate side chains on rings A and B of coproporphyrinogen III to the corresponding vinyl groups to yield protoporphyrinogen IX. Here, the sequence of the two decarboxylation steps during HemN catalysis was investigated. A reaction intermediate of HemN activity was isolated by HPLC analysis and identified as monovinyltripropionic acid porphyrin by mass spectrometry. This monovinylic reaction intermediate exhibited identical chromatographic behavior during HPLC analysis as harderoporphyrin (3-vinyl-8,13,17-tripropionic acid-2,7,12,18- tetramethylporphyrin). Furthermore, HemN was able to utilize chemically synthesized harderoporphyrinogen as substrate and converted it to protoporphyrinogen IX. These results suggest that during HemN catalysis the propionate side chain of ring A of coproporphyrinogen III is decarboxylated prior to that of ring B. by Walter de Gruyter.

Process For Preparing Porphyrin Derivatives, Such As Protoporphyrin (IX) And Synthesis Intermediates

The present invention relates to a process for preparing a porphyrin of formula (I), optionally in the form of a salt with an alkali metal and/or in the form of a metal complex: in which: R and R′ are as defined in claim 1, comprising: a step of condensation, in an acidic medium, between a dipyrromethane of formula (II): in which R′b is as defined above for (I), and a dipyrromethane of formula (III): in which R″ is as defined in claim 1, and also the compounds of formula (III).