1065269-88-6

Basic information

• Product Name: Methyl 4-(2-Iodoethyl)benzoate
• Synonyms: Methyl 4-(2-Iodoethyl)benzoate;4-(2-Iodoethyl)-benzoic acid mehyl ester
• CAS NO: 1065269-88-6
• Molecular Formula: C₁₀H₁₁IO₂
• Molecular Weight: 290.09761
• Product Categories: Aromatics, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1065269-88-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 4-(2-Iodoethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(2-Iodoethyl)benzoate(1065269-88-6)
• EPA Substance Registry System: Methyl 4-(2-Iodoethyl)benzoate(1065269-88-6)

Safety Data

• Hazardous Substances Data: 1065269-88-6(Hazardous Substances Data)

Usage

Description

Methyl 4-(2-iodoethyl)benzoate, a 2-pyridone derivative, is a chemical compound with significant potential in the medical field. It is characterized by its unique structure that allows it to act as an EP4 receptor agonist, which is crucial for its therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Methyl 4-(2-iodoethyl)benzoate is used as a pharmaceutical agent for the treatment of peripheral arterial disease. As an EP4 receptor agonist, it plays a vital role in promoting the dilation of blood vessels, which can help improve blood flow and alleviate the symptoms associated with peripheral arterial disease. This application takes advantage of the compound's ability to modulate the EP4 receptor, which is known to be involved in various physiological processes related to inflammation and vascular health.

Upstream product

• 65787-72-6 methyl 4-(2-chloroethyl)benzoate 
• 46190-45-8 4-(2-hydroxyethyl)benzoic acid methyl ester 

Downstream Products

• 1091599-62-0 methyl 4-[2-(3,5-dichloro-6-methyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate 
• 1091599-76-6 methyl 4-[2-(5-bromo-3-chloro-6-methyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate 
• 1065269-89-7 diallyl bis{2-[4-(methoxycarbonyl)phenyl]ethyl}malonate 
• 1091599-69-7 tert-butyl 4-{2-[6-(bromomethyl)-3,5-dichloro-2-oxopyridin-1(2H)-yl]ethyl}benzoate 
• 1091599-70-0 tert-butyl 4-{2-[6-(acetoxymethyl)-3,5-dichloro-2-oxopyridin-1(2H)-yl]ethyl}benzoate 
• 1091599-71-1 tert-butyl 4-{2-[3,5-dichloro-6-(hydroxymethyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoate 
• 1091599-74-4 tert-butyl 4-[2-(3,5-dichloro-6-formyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate 
• 1091599-68-6 tert-butyl 4-[2-(3,5-dichloro-6-methyl-2-oxopyridin-1(2H)-yl)ethyl]benzoate 
• 1091599-84-6 4-[2-(3,5-dichloro-6-methyl-2-oxopyridin-1(2H)-yl)ethyl]benzoic acid 
• 1201823-93-9 tert-butyl 4-{2-[3,5-dichloro-6-(2,3-dihydro-1H-indol-1-ylmethyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoate 
• 1201818-27-0 4-{2-[3,5-dichloro-6-(2,3-dihydro-1H-indol-1-ylmethyl)-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid 
• 1201818-29-2 4-{2-[3,5-dichloro-2-oxo-6-{[(2S)-2-propylpyrrolidin-1-yl]methyl}pyridin-1(2H)-yl]ethyl}benzoic acid mono-trifluoroacetate 
• 1201818-31-6 4-{2-[3,5-dichloro-6-{[(2R)-2-isobutylpyrrolidin-1-yl]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoic acid monotrifluoroacetate 
• 1201818-33-8 tert-butyl 4-{2-[3,5-dichloro-6-{[cyclopentyl(methyl)amino]methyl}-2-oxopyridin-1(2H)-yl]ethyl}benzoate 

Relevant articles and documents

LACTAM-SUBSTITUTED DICARBOXYLIC ACIDS AND USE THEREOF

The present application relates to novel lactam-substituted dicarboxylic acid derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

Enantioselective polyene cyclization via organo-SOMO catalysis

The first organocatalytic enantioselective radical polycyclization has been accomplished using singly occupied molecular orbital (SOMO) catalysis. The presented strategy relies on a selective single-electron oxidation of chiral enamines formed by condensation of polyenals with an imidazolidinone catalyst employing a suitable copper(II) oxidant. The reaction proceeds under mildly acidic conditions at room temperature and shows compatibility with an array of electron-poor as well as electron-rich functional groups. Upon termination by radical arylation followed by subsequent oxidation and rearomatization, a range of polycyclic aldehydes were accessed (12 examples, 54?77% yield, 85?93% ee). The enantioselective formation of up to six new carbocycles in a single catalyst-controlled cascade is described. Evidence for a radical-based cascade mechanism is indicated by a series of experimental results.