46190-45-8

Basic information

• Product Name: methyl 4-(2-hydroxyethyl)benzoate
• Synonyms: methyl 4-(2-hydroxyethyl)benzoate;Benzoic acid, 4-(2-hydroxyethyl)-, methyl ester
• CAS NO: 46190-45-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• Mol File: 46190-45-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 134 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.143±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.72±0.10(Predicted)
• CAS DataBase Reference: methyl 4-(2-hydroxyethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-hydroxyethyl)benzoate(46190-45-8)
• EPA Substance Registry System: methyl 4-(2-hydroxyethyl)benzoate(46190-45-8)

Safety Data

• Hazardous Substances Data: 46190-45-8(Hazardous Substances Data)

Upstream product

• 1076-96-6 methyl 4-vinylbenzoate 
• 1075-49-6 4-ethenylbenzoic acid 
• 1584730-57-3 methyl 4-[2-(phenylsilyl)ethyl]benzoate 
• 36099-25-9 <4-(methoxycarbonyl)phenyl>oxirane 
• 1571-08-0 methyl 4-formylbenzoate 
• 106918-31-4 1-methoxy-2-(4-carbomethoxyphenyl)ethylene 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 540-51-2 2-bromoethanol 

Downstream Products

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 7364-20-7 4-ethyl-benzoic acid methyl ester 
• 113249-86-8 Methyl 4-(2-Trimethylsiloxyethyl)benzoate 
• 819883-83-5 4-(2-fluoroethyl)benzoic acid methyl ester 
• 46112-46-3 4-(2-((tert-butyldimethylsilyl)oxy)ethyl)benzoic acid 
• 920006-92-4 4-(2-hydroxy-ethyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 819883-84-6 4-(2-fluoroethyl)benzoic acid 
• 113249-96-0 Dimethyl 4,4'-<(1,1-Ethanediyl)bis(oxy)bis(1,2-ethanediyl)>bisbenzoate 
• 113249-94-8 Dimethyl 4,4'-<(1,1-Butanediyl)bis(oxy)bis(1,2-ethanediyl)>bisbenzoate 
• 113249-90-4 Dimethyl 4,4'-<(2-Bromo-1,1-ethanediyl)bis(oxy)bis(1,2-ethanediyl)>bisbenzoate 
• 113249-92-6 Dimethyl 4,4'-<(3-Benzyloxy-1,1-propanediyl)bis(oxy)bis(1,2-ethanediyl)>bisbenzoate 
• 1115987-05-7 4-[2-(t-butyldiphenylsilyloxy)ethyl]benzoic acid methyl ester 
• 1065269-88-6 methyl 4-(2-iodoethyl)benzoate 
• 1435685-18-9 4-(2-fluoroethyl)-N-(4-(4-(2-methoxyphenyl)-1,4-diazepan-1-yl)butyl)benzamide 

Relevant articles and documents

Ni-Catalyzed Formal Cross-Electrophile Coupling of Alcohols with Aryl Halides

Direct coupling of unactivated alcohols remains a challenge in current synthetic chemistry. We herein demonstrate a strategy building upon in situ halogenation/reductive coupling of alcohols with aryl halides to forge Csp2-Csp3 bonds. The combination of 2-chloro-3-ethylbenzo[d]oxazol-3-ium salt (CEBO) and TBAB as the mild bromination reagents enables rapid transformation of a wide range of alcohols to their bromide counterparts within one to 5 min in CH3CN and DMF, which is compatible with the Ni-catalyzed cross-electrophile coupling conditions in the presence of a chemical reductant. The present method is suitable for arylation of a myriad of structurally complex alcohols with no need for prepreparation of alkyl halides. More importantly, the mild and kinetically rapid bromination process has shown good selectivity in the bromination/arylation of symmetric diols and less sterically hindered hydroxyl groups in polyols, thus offering promise for selective functionalization of diols and polyols without laborious protecting/deprotecting operations. The practicality of this work is also evident in the arylation of a number of carbohydrates, drug compounds, and naturally occurring alcohols.

PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4

The present invention encompasses compounds of formula (I) wherein the groups R1,A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Piers' borane-mediated hydrosilylation of epoxides and cyclic ethers

We report the first diarylborane-catalysed hydrosilylation of epoxides and cyclic ethers. Mechanistic studies on the in situ generated Piers' borane (C6F5)2BH with hydrosilanes in the presence of an epoxide revealed that an alkyloxy(diaryl)borane (C6F5)2BOR is readily formed as a catalytically competent species for the outer-sphere hydrosilylation of epoxides and cyclic ethers.