106896-48-4 Usage
Description
3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER, also known as Methyl 3-Amino-2-bromobenzoate, is an organic compound with the molecular formula C8H8BrNO2. It is a derivative of benzoic acid, featuring a bromine atom at the 2nd position, an amino group at the 3rd position, and a methyl ester group attached to the carboxylic acid. 3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER is characterized by its potential reactivity and structural diversity, making it a versatile building block in organic synthesis and a promising candidate for various applications.
Uses
Used in Pharmaceutical Industry:
3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER is used as a key intermediate in the synthesis of Carbazole-based compounds, which are known for their diverse biological activities and potential applications in the development of new drugs. These carbazole derivatives have been explored for their anticancer, anti-inflammatory, and antimicrobial properties, among others.
Used in Enzyme Inhibition:
3-AMINO-2-BROMO-BENZOIC ACID METHYL ESTER is also utilized as an inhibitor of the enzyme Indoleamine 2,3-dioxygenase (IDO). IDO is an enzyme involved in the metabolism of tryptophan, an essential amino acid, and its inhibition has been linked to the modulation of immune responses. By targeting IDO, this compound may have potential applications in the treatment of various diseases, including cancer and neurodegenerative disorders, where immune system modulation is crucial.
Check Digit Verification of cas no
The CAS Registry Mumber 106896-48-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,8,9 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 106896-48:
(8*1)+(7*0)+(6*6)+(5*8)+(4*9)+(3*6)+(2*4)+(1*8)=154
154 % 10 = 4
So 106896-48-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H8BrNO2/c1-12-8(11)5-3-2-4-6(10)7(5)9/h2-4H,10H2,1H3
106896-48-4Relevant articles and documents
Exploration of Biaryl Carboxylic Acids as Proton Shuttles for the Selective Functionalization of Indole C-H Bonds
Pi, Jing-Jing,Lu, Xiao-Yu,Liu, Jing-Hui,Lu, Xi,Xiao, Bin,Fu, Yao,Guimond, Nicolas
, p. 5791 - 5800 (2018/05/14)
A survey of diversely substituted 2-arylbenzoic acids were synthesized and tested for use as proton shuttle in the direct arylation of indoles with bromobenzenes. It was found that 3-ethoxy-2-phenylbenzoic acid gives superior yield and selectivity for this class of substrates.
SUBSTITUTED BENZENE COMPOUNDS
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Page/Page column 348, (2012/11/06)
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Electrophilic bromination of meta-substituted anilines with N-bromosuccinimide: Regioselectivity and solvent effect
Bartoli, Sandra,Cipollone, Amalia,Squarcia, Antonella,Madami, Andrea,Fattori, Daniela
experimental part, p. 1305 - 1308 (2009/12/24)
N-Bromosuccinimide-mediated electrophilic aromatic bromination of a series of anilines substituted with an electron-with-drawing group in the meta position was investigated. The regioselectivity of the reaction is markedly dependent on the polarity of the solvent and the bromination reaction can be tuned by appropriate selection of the reaction medium. Georg Thieme Verlag Stuttgart.
